Meeko -m Unrecognized for Preparing Macrocycles

[selmifiqhi]

Hello, I used meeko 0.4.0 to prepared macrocycles compound and run this code.

mk_prepare_ligand.py -i PPD_A.sdf -m -o PPD.pdbqt

But the meeko give error message like this:

mk_prepare_ligand.py: error: unrecognized arguments: -m

Is there any change in the argument? Thank you.

[diogomart]

Yes, we dropped the -m option, now macrocycles are flexible by default.