GLSS-DF-0002-R1|TP
GLSS-DF-0003-R1
GLSS-DF-0004-TP
GLSS-DF-0010-R1
GLSS-DF-0012-R1|TP
GLSS-19-0268-R1-02D (sequenced at DF)
GLSS-19-0271-R1-02D (sequenced at DF)
It seems off that some of these samples would have quite altered genomes at one time point, but nearly unaltered at the other.
Case example with canonical Chr7 gain, Chr10 loss at primary diagnosis.
Unexpected stability at recurrence, but it still picks up an EGFR amplification.
Since this affected more than ~50% of the cases from this dataset we are launching an investigation to find out whether this is a data quality issue (coverage, low purity) or another matter.
The following samples had flatline CNV profiles:
It seems off that some of these samples would have quite altered genomes at one time point, but nearly unaltered at the other.
Case example with canonical Chr7 gain, Chr10 loss at primary diagnosis.![glss-df-0003-tp-01d-wxs-imr04g](https://user-images.githubusercontent.com/6731211/53526317-dc3b3180-3ab1-11e9-9187-55d44e9c33af.png)
Unexpected stability at recurrence, but it still picks up an EGFR amplification.![glss-df-0003-r1-01d-wxs-bkukvh](https://user-images.githubusercontent.com/6731211/53526324-e0674f00-3ab1-11e9-9951-85c5e6866079.png)
Since this affected more than ~50% of the cases from this dataset we are launching an investigation to find out whether this is a data quality issue (coverage, low purity) or another matter.