Assess impact of purity on M2 calling sensitivity

fpbarthel / GLASS

GLASS consortium

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Assess impact of purity on M2 calling sensitivity #134

Closed fpbarthel closed 5 years ago

fpbarthel commented 5 years ago

Assess the impact of purity on M2 calling sensitivity
Consider adjusting MF calculation based on purity

Moved from https://github.com/TheJacksonLaboratory/GLASS/issues/120

Kcjohnson commented 5 years ago

This issue was resolved during the revision process. There was no association between mutation frequency and TITAN estimated purity. We observed that there was a weak association between mutation frequency and an alternative purity estimate from Sequenza.