The distribution of Sequenza cellularity (tumor purity) values in the GLASS-dataset (n=680 samples) looks like this:
The number of samples with cellularity:
<10% = 0
<15% = 19
<20% = 35
<25% = 55
<30% = 93
<35% = 125
<40% = 150
Questions at this point: What is the best cutoff for cellularity? Which low cellularity samples should be filtered out for further analyses? Or is it even necessary to set a cutoff?
__
The following plots show copy-number-plots of the 5 samples with the lowest cellularity
The distribution of Sequenza cellularity (tumor purity) values in the GLASS-dataset (n=680 samples) looks like this:
The number of samples with cellularity:
Questions at this point: What is the best cutoff for cellularity? Which low cellularity samples should be filtered out for further analyses? Or is it even necessary to set a cutoff?
__ The following plots show copy-number-plots of the 5 samples with the lowest cellularity
GLSS-DF-0007-R1-01D-WXS-C7TKYT (cellularity = 0.10)
GLSS-DF-0012-R1-01D-WXS-QGRYN1 (cellularity = 0.10)
GLSS-SM-R063-R1-01D-WXS-SF2PHH (cellularity = 0.10)
GLSS-SM-R069-TP-01D-WXS-EIPTR4 (cellularity = 0.11)
GLSS-SM-R099-R1-01D-WXS-I52D70 (cellularity = 0.12)