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fpbarthel / GLASS

GLASS consortium
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Multiple Treatment/KPS Entries Between Surgeries #66

Closed moskalika closed 5 years ago

moskalika commented 5 years ago

Which value to use for KPS if multiple are available between surgeries? We could take the most recent one, a median, or also see if we want to take the values after adjuvant treatment has been completed (XRT/Chemo)? Some of the samples have a pretty wide range (ei. 40-90)

moskalika commented 5 years ago

There is a similar situation for radiotherapy and chemotherapy. Is it okay if I add the numbers between the entries? (For example if there were two entries for radiation after surgeries, one 40Gy and the second is 14Gy, I would put 54 after TP surgery)

wisekh6 commented 5 years ago

I think we should talk with sample providers. I also had a similar issue from the 2015 paper. Let’s just leave a note so that we re-address those issues.

Thanks

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On Oct 10, 2018, at 10:17 AM, moskalika notifications@github.com wrote:

There is a similar situation for radiotherapy and chemotherapy. Is it okay if I add the numbers between the entries? (For example if there were two entries for radiation after surgeries, one 40Gy and the second is 14Gy, I would put 54 after TP surgery)

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Kcjohnson commented 5 years ago

@moskalika These are great questions. For the KPS, I vote that we report the median performance status since we really are interested in the most stable estimate. I saw one case where there was a 90 reported one week and 40 the next, with no surgical intervention in between.

I would add the total dose as you suggested for the treatments. I am not sure how much of this information we will end up using in the final analysis due to missingness, but I'd presume that adding would better represent the treatments that tumor has "experienced".

Kcjohnson commented 5 years ago

Closing this for now. Please reopen or raise new issue if there are additional clinical questions/ambiguities.