Yes. Based on biological knowledge, if the cells in your sample are likely all diploids, you can regard the detected polyploid cells as multiplets. Indeed, scPloidy can detect aggregation of cells of the same cell type, which cannot be detected by RNA-seq based algorithms (e.g., Scrublet, DoubletFinder, DoubletDecon).
Yes. Based on biological knowledge, if the cells in your sample are likely all diploids, you can regard the detected polyploid cells as multiplets. Indeed, scPloidy can detect aggregation of cells of the same cell type, which cannot be detected by RNA-seq based algorithms (e.g., Scrublet, DoubletFinder, DoubletDecon).