MMSplice on non-human VCF files

gagneurlab / MMSplice_MTSplice

Tissue-specific variant effect predictions on splicing

MIT License

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MMSplice on non-human VCF files #2

Closed vidhyajagannathan closed 5 years ago

vidhyajagannathan commented 5 years ago

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Description

Can I run mmsplice on non-human VCF files. I am interested in running them on horse/dog/cow variant files

s6juncheng commented 5 years ago

Hi @vidhyajagannathan, thanks for interested in MMSplice. MMSplice was developed with human data, although there should be some correlations between human splicing regulatory code and other species, it might not generalize well. If you have standard gtf annotation file from ensembl, you might be able to still run MMSplice, but I would be cautious when interpreting the results.