search

gao-lab / GLUE

Graph-linked unified embedding for single-cell multi-omics data integration
MIT License
364 stars 55 forks source link

Can Glue be used to integrate single-cell transcriptome, Bulk-proteomics, and metabonomics? #9

Closed zydf1996 closed 2 years ago

zydf1996 commented 2 years ago

Dear developers, Thank you for sharing your code. I want to take this opportunity to ask whether we can use your Glue program to integrate simple single-cell transcriptome with general proteomics and metabonomics. This is very important to me. Thank you for your answer. Best wishes, zjz

Jeff1995 commented 2 years ago

Thanks for your interest in GLUE!

What kind of integration do you intend to do?

Is it more like:

  1. Deconvolution of these bulk data with help from scRNA-seq;

Or

  1. Unpaired alignment of scRNA-seq and several bulk samples?

If it's the first case, I'm afraid that's not what GLUE is designed for.

In the second case, I think that would depend on how many bulk samples you have. If there is a sufficient number of bulk samples, it would be worth a try.

zydf1996 commented 2 years ago

Thanks for your interest in GLUE!

What kind of integration do you intend to do?

Is it more like:

  1. Deconvolution of these bulk data with help from scRNA-seq;

Or

  1. Unpaired alignment of scRNA-seq and several bulk samples?

If it's the first case, I'm afraid that's not what GLUE is designed for.

In the second case, I think that would depend on how many bulk samples you have. If there is a sufficient number of bulk samples, it would be worth a try. Thank you so much. What i want to do is the second case. It may take longer to try ^-^.

Jeff1995 commented 2 years ago

Sure! Let me know if there are further issues.