Intuitive understanding of `txnE` and `txnStrength`

[ilykos]

Is there a formula or ratio of how the txnE and txnStrength parameters should relate to the bin width? Should these always kept at default value or is there a rule of thumb for this parameter?

Quote from snakefile:

# control segmentation - higher (e.g. 0.9999999) leads to higher specificity and fewer segments
# lower (e.g. 0.99) leads to higher sensitivity and more segments
ichorCNA_txnE:  0.9999

# control segmentation - higher (e.g. 10000000) leads to higher specificity and fewer segments
# lower (e.g. 100) leads to higher sensitivity and more segments
ichorCNA_txnStrength:  500