cmungall
commented
9 years ago We have no way of saying in GO if it is a subtype, a part of or overlaps with autophagy until we define the start and end of autophagy
it is fairly loose
[Term]
id: GO:0006914
name: autophagy
namespace: biological_process
alt_id: GO:0016238
def: "The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464]
subset: goslim_chembl
subset: goslim_generic
subset: goslim_pir
subset: goslim_pombe
xref: Wikipedia:Autophagy_(cellular)
is_a: GO:0044248 ! cellular catabolic process
relationship: only_in_taxon NCBITaxon:2759 ! EukaryotaThis is also vague:
[Term]
id: GO:0032258
name: CVT pathway
namespace: biological_process
def: "A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast." [PMID:12865942, PMID:15659643]
synonym: "cytoplasm to vacuole targeting" EXACT []
synonym: "cytoplasm-to-vacuole targeting" EXACT []
is_a: GO:0006623 ! protein targeting to vacuole
relationship: has_part GO:0006624 ! vacuolar protein processing
I am reviewing some of Trey Idekar's work on autophagy and he has suggested cvt pathway be related to autophagy. I would like to know if the autophagy team discussed this issue? From what I know cvt is a constitutive process and is not under starvation conditions. I am looking at this review - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843786/ that says cvt pathway is a type of selective autophagy.
Let me know your thoughts.
Rama