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This repository hosts the tracker for issues pertaining to GO annotations.
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PANTHER:PTN000205059 (PTHR11760) DNA repair and nucleus #1509

Closed ValWood closed 7 years ago

ValWood commented 7 years ago

Is mapping a clearly cytoplasmic ribosome protein to nucleus and DNA repair.

seems to come from one source: https://www.ncbi.nlm.nih.gov/pubmed/8641296

Is this likely to be physiological role? I can't see any further follow up since 1996......

pgaudet commented 7 years ago

Hi Val,

I see several sources for the double activity: http://www.yeastgenome.org/locus/S000005122/overview http://www.uniprot.org/uniprot/P62908 http://flybase.org/reports/FBgn0002622.html

PMID:7775413 PMID:8641296 PMID:11561734 PMID:15707971 PMID:14706345 PMID:16737853 PMID:17560175 PMID:18610840

Are we talking about the same family ?

Thanks, Pascale

ValWood commented 7 years ago

Something a bit strange here: Then I look in AmiGO, it is this family associated with RPS3 http://amigo.geneontology.org/amigo/gene_product/SGD:S000005122

But if I go back a page to here

http://amigo.geneontology.org/amigo/search/bioentity?q=*:*&fq=isa_partof_closure:%22GO:0002181%22&fq=isa_partof_closure:%22GO:0006281%22

it's 30s/40s ribosomal protein s3 pthr11760 which makes much more sense? ?

ValWood commented 7 years ago

Maybe because there are 2 families. Anyway I see what you mean. This appears to have a repair role. I wonder why SGD did not make this annotation- will check. There could be evidence that this is not the physiological role if its an in vitro assay.....

ValWood commented 7 years ago

This one is OK. SGD will add repair role BP annotation.