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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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PTN001093729 regulation of mitochondrial translation #1516

Closed ValWood closed 6 years ago

ValWood commented 7 years ago

The "Pan5" branch of the 2-dehydropantoate 2-reductase family is annotated to "regulation of mitochondrial translation" which seems incorrect for pan5 family. It seems to be coming from a protein CBS2, which is not so closely related to the PAN5 branch (pombe does not have this protein). It might be an example of "duplication and divergence"

It seems unlikely that pan5 has any role in mitochondrial translation (pombe or cerevisiae). In fact, there is a very strong morphology phenotype associated with fission yeast mitochondrial translation and the pan5 deletion does not have this phenotype.

marcfeuermann commented 6 years ago

It is indeed an example of "duplication and divergence". All annotation propagations from CBS2 have been removed.