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This repository hosts the tracker for issues pertaining to GO annotations.
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KW-0251 spt6 nucleosome remodelling protein is not a "translation elongation factor" #1737

Closed ValWood closed 1 year ago

ValWood commented 6 years ago

missapplied KW

https://www.pombase.org/gene/SPAC1F7.01c http://www.uniprot.org/uniprot/S6BMF4

This seems to be a rule base issue...

pgaudet commented 6 years ago

Hi,

As part of the transcription refactoring we plan to restore transcription elongation factor activity; sounds like this is the term needed here, right ?

Thanks,

Pascale

ValWood commented 6 years ago

I'm still not sure about this. A lot of things called "elongation factors" are just "required for elongation, many turn out to be very indirect.

Spt6 as far as I can tell has a role in nucleosome positioning probably by recruiting something to chromatin) and seems to affect transcription generally, and therefore "affects" elongation.

To me "transcription elongation factor" means "BP transcription elongation" and nothing else.

Problems: When we know the activity of an "elongation factor" it will have annotations to both its "real activity" and "elongation factor" to describe the same function?

Do you envisage that everything involved in "transcription elongation" would be annotated to this term? Or just a subset? If so, how do you decide?

I think it could lead to more annotation inconsistency, not less.....

ValWood commented 1 year ago

Closing. The annotation is correct to H3-H4 histone complex chaperone activity

There is an incorrect InterPro mapping, I will deal with that later