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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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checkpoint clamp complex protein Rad1, not a nuclease, remove KW-0378 #1771

Closed ValWood closed 1 year ago

ValWood commented 6 years ago

misapplied KW

checkpoint clamp complex protein Rad1 https://www.pombase.org/gene/SPAC1952.07

http://www.uniprot.org/uniprot/P22193 has Hydrolase KW-0378 nuclease KW-0540

sylvainpoux commented 6 years ago

Hi Val,

done

Sylvain

ValWood commented 6 years ago

Hi Sylvain,

Did you address for all species? I just spotted that the annotation comes from human 3'-5' exonuclease activity Source: UniProtKB IDA PMID: 9660799

and Source: UniProtKB-EC

This is from a paper http://www.uniprot.org/citations/9660799

which is refuted https://www.ncbi.nlm.nih.gov/pmc/articles/PMC317084/

(I asked a pombe expert who works on Rad1, and it isn't a nuclease at all... it's a DNA clamp)

So, who would we assign this one to?

And is there a way to add this paper to a "blacklist" to make sure it is not used again? I think we talked about this as part of our QC procedure?

@pgaudet

pgaudet commented 6 years ago

Thanks @ValWood I added this to our QC ideas notes.

Pascale

ValWood commented 1 year ago

I raised a dispute for human https://www.uniprot.org/uniprotkb/O60671/entry for the single 1999 annotation

It still has old nuclease annotation (and an EC SPKW and a PAINT mapping)

sylvainpoux commented 1 year ago

Hi @ValWood I removed this annotation. Many thanks for pointing this out Sylvain