ValWood
commented
6 years ago This is a nice description of the conserved pathway
This translational response to amino acid depletion is medi- ated by proteins of the Gcn2 protein kinase family, which are conserved throughout eukaryotes (4). Gcn2 is activated by deacylated tRNAs and phosphorylates the translation initiation factor eIF2, which is required to deliver the initiator tRNA to the ribosome, in its α-subunit. eIF2 is a GTP-binding protein whose activation requires the activity of the GTP/GDP-exchange factor eIF2B, which facilitates the exchange of GDP with GTP. Phos- phorylated eIF2 binds to eIF2B with high affinity, behaving as a competitive inhibitor. As eIF2 is more abundant than eIF2B, this binding leads to the rapid sequestration of all cellular eIF2B and thus triggers a global down-regulation of translation (5).
summary of the biology from: PMID:29432178
One of the best-studied examples is the response to amino acid starvation. Amino acid starvation causes an accumulation of uncharged tRNAs, which activate a signaling pathway that leads to a reduction of the translation of the majority of cellular mRNAs. Simultaneously, the translation of specific mRNAs, some of them encoding key transcription factors, is induced. These transcription factors, in turn, launch a transcriptional program that promotes cellular survival under stress. This program is called the general amino acid control (GAAC) in yeast (2) and the amino acid response (AAR) in mammals (3).
the current term "cellular response to amino acid starvation" Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids. PMID:7765311 Definition (GO:0070321 GONUTS page) Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating deprivation of nitrogen.
we also have GO:0070321 regulation of translation in response to nitrogen starvation
which seems like the translational repression represented by this pathway?
but it has no annotation or reference . If it is it might be better as regulation of translation in response to amino acid starvation?
the term I would like is "signaling in response to amino acid starvation" Any signaling that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.