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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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Document how we differentiate different kinds of regulation #1991

Open pgaudet opened 6 years ago

pgaudet commented 6 years ago

Action item from 2018 NYC meeting

vanaukenk commented 6 years ago

See:

https://github.com/geneontology/go-annotation/issues/1532

http://geneontology.org/page/regulation http://geneontology.org/page/ontology-relations http://wiki.geneontology.org/index.php/Category:Regulation

From Paul T.'s GO Handbook Chapter (italics are mine):

"But a gene product can affect a biological objective even if it does not act strictly within the process, and in these cases a GO annotation aims to specify that relationship insofar as it is known. First, a gene product can control when and where the program is executed; that is, it might regulate the program. In this case, the gene product acts outside of the program, and controls (directly or indirectly) the activity of one or more gene products that act within the program."

ValWood commented 6 years ago

I have an analysis in a ticket somewhere where I went through all the pombe annotation and classified different types of regulation (broadly). Might be a useful starting point.

Need to find it . @pgaudet mentioned it recently. I'll hunt it out late.

pgaudet commented 6 years ago

1532