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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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Determination of adult lifespan #2017

Open Antonialock opened 6 years ago

Antonialock commented 6 years ago

Hello,

There are 15 genes in human annotated to "determination of adult lifespan" (mix of IMP, IDA, IBA, IEA...) by Uniprot, Go central & WB.

This is defined as: The control of viability and duration in the adult phase of the life-cycle.

Do we really think that we have a process determining this?

I'm guessing this would also be true for worms?

It looks like these annotations might just reflect phenotypes from viability assays?

Its only child term is " insulin receptor signaling pathway involved in determination of adult lifespan " It is a sibling term to menopause

not sure who should be tagged to this issue aside form uniprot and wormbase

ValWood commented 1 year ago

I also think this is an odd GO term. Longevity is a phenotype.

Pomnbase has 1689/5050 genes so far affecting longevity! https://www.pombase.org/results/from/id/695f1425-85f4-494a-9f62-cb0e768d0e1c covering every process

Antonialock commented 1 year ago

Yes I think this should go....

ValWood commented 1 year ago

It's quite interesting, but not unsurprising to see that every slim process is implicated in "ageing" https://www.pombase.org/slim:bp_goslim_pombe/from/id/695f1425-85f4-494a-9f62-cb0e768d0e1c