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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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NACA UniPROT description inconsistent with GO annotation #2120

Closed ValWood closed 2 years ago

ValWood commented 5 years ago

https://www.uniprot.org/uniprot/Q13765#family_and_domains

THis is an odd case I wondered if somehow the incorrect entry was annotated?

Uniprot describes as NACA.

The evidence I'm currently looking at seems stronger for the transcription factor role. So far I can only see a TAS for translation

What is the EXP EVIDENCE FOR Nascent polypeptide-associated complex subunit alpha?

ValWood commented 5 years ago

This does seem to be Nascent polypeptide-associated complex subunit alpha there is a NAture paper that could be used for GO. MAybe it is multifunctional. I'll take a closer look at this one.

pgarmiri commented 5 years ago

There are also 4 structural papers in the Interaction/Subunit Structure section of the UniProt entry.

"The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions." Beatrix B., Sakai H., Wiedmann M. J. Biol. Chem. 275:37838-37845(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH BTF3, ASSOCIATION WITH RIBOSOMES, SUBCELLULAR LOCATION. "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function." Stilo R., Liguoro D., di Jeso B., Leonardi A., Vito P. Biochem. Biophys. Res. Commun. 303:1034-1041(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FADD. "The crystal structure of the human nascent polypeptide-associated complex domain reveals a nucleic acid-binding region on the NACA subunit." Liu Y., Hu Y., Li X., Niu L., Teng M. Biochemistry 49:2890-2896(2010) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 84-136, SUBUNIT, DNA/RNA-BINDING REGION, SUBCELLULAR LOCATION. "Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit." Wang L., Zhang W., Wang L., Zhang X.C., Li X., Rao Z. Protein Cell 1:406-416(2010) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 79-132, SUBUNIT.

ValWood commented 2 years ago

transcription factor annotations are purged.