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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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IPR003606 Nuclear protein Zn2+-binding #216

Closed gocentral closed 9 years ago

gocentral commented 18 years ago

Hello,

IPR003606 Nuclear protein Zn2+-binding has several mappings but according to the description the function of this domain is not well characterized.

Maybe these mappings should be removed? (except zinc ion binding)

Also, related entries (IPR001214, IPR003616 and IPR007728) do not have amy mappings. Perhaps IPR001214 Nuclear protein SET could have "GO:0018024 histone-lysine N-methyltransferase activity "

Thanks, Pascale

Reported by: pgaudet

Original Ticket: "geneontology/annotation-issues/216":https://sourceforge.net/p/geneontology/annotation-issues/216

gocentral commented 18 years ago

Original comment by: pgaudet

gocentral commented 18 years ago

Logged In: YES user_id=545117

Domains are always difficult - if they always stayed as domains I could write rigid rules about putting very limited GO mapping on them but they often start as families and get retyped to domains (or visa versa) and take their GO mapping with them. In this case, the mappings are true as family statements for all the proteins this domain is found in. I generally ignore type for Process and Subcellular location but only add specific function where one is found, the exception to this being when a protein has an EC no. since I tend to argue that all domains in a protein contribute to this function, not just the catalytic site. IPR003606 does actually follow these rules. This is also true for IPR007728 (pre-Set) but not Set or Post-Set which seem to turn up in much more diverse ses of proteins.

Sandra

Original comment by: orchard

gocentral commented 18 years ago

Original comment by: orchard