annotation review Q13127 Gene REST,

[ValWood]

A zinc finger protein RE1-silencing transcription factor

outward rectifier potassium channel activity Source: UniProtKB not so sur about some of the others either, but this is a major outlier

[RLovering]

Hi Val

if you look on my spreadsheet there is a list of emails I have sent to people about these 'outliers' Reactome is going to be addressing this (on the note tab)

https://docs.google.com/spreadsheets/d/17mISqgr4JtlHO2ggpibcQ5pbOkes1d8v1Hh81nudpVg/edit?usp=sharing

Ruth

[pgaudet]

Removed by @milarolo

@RLovering Q13127 is not in the spreadsheet - or am I missing something ?

[RLovering]

It is on my spreadsheet see row 105 and row 4 on the notes tab

[pgaudet]

OK thanks, I've added that the enzymatic activity has been reviewed.

We still need to review the transcription part.

Pascale

[ValWood]

OK I wasn’t really looking at this from the transcription overhaul perspective. I was looking because one of our “conserved unknowns” , the ortholog of ZNF277 was published this week: https://www.ncbi.nlm.nih.gov/pubmed/30530495 https://www.pombase.org/gene/SPAC19B12.07c

In human, this (ZNF277) is annotated to many transcription terms, but I hadn’t made this inference in pombe since the evidence did not seem strong lots if IEA one ISA to https://www.uniprot.org/uniprot/Q8VIG1 which is how I ended up looking at this again.

It’s all very odd because “REST” does not appear to be the ortholog of ZNF277 https://www.flyrnai.org/cgi-bin/DRSC_orthologs.pl?input_species=4896&output_species=0&additional_filter=None&search_fields=***&search_datasets=***&gene_list=SPAC19B12.07c

Although they both have multiple zinc fingers. (mouse has a ZNF277)

I hope to know more about SPAC19B12.07c/ZNF277 one Francois has curated PMID:30530495

Cheers Val

[ValWood]

i.e ZNF277 needs looking at...

[pgaudet]

Disputed in Protein2GO.