MAtrix (ILV5) amino acid metabolism/mitochondrial organization

[ValWood]

ILV5 is described as Acetohydroxyacid reductoisomerase and mtDNA binding protein;

so do you think these are OK? or are they just downstream effects

• [x] ILV5 | Acetohydroxyacid reductoisomerase and mtDNA binding protein |   | mitochondrial genome maintenance |   | SGD | Saccharomyces cerevisiae S288C | IGI | SGD:S000000956 | family not named pthr21371 | gene |   | PMID:18826960 | 20120501   | ILV5 | Acetohydroxyacid reductoisomerase and mtDNA binding protein |   | mitochondrial genome maintenance |   | SGD | Saccharomyces cerevisiae S288C | IGI | SGD:S000003679 | family not named pthr21371 | gene |   | PMID:18826960 | 20120501   | ILV5 | Acetohydroxyacid reductoisomerase and mtDNA binding protein |   | mitochondrial genome maintenance |   | SGD | Saccharomyces cerevisiae S288C | IMP |   | family not named pthr21371 | gene |   | PMID:7621838

From what I can see these are mainly GIs (supressors) https://www.yeastgenome.org/reference/S000127907 which would not be surprising that this was a long range phenotype. They don't appear to suggest a mechanism.

If you think it is OK, I can add an exception for this.

[ValWood]

also (this does seem to be indirect)

• [x] KGD2 | Dihydrolipoyl transsuccinylase |   | mitochondrial genome maintenance |   | SGD | Saccharomyces cerevisiae S288C | IGI | SGD:S000004676 | family not named pthr43416 | gene |   | PMID:10869431 | 20100603

[srengel]

for ILV5, looks that that one may be bifunctional. different mutants cause loss of either the branched chain amino acid biosynthetic function or the mtDNA stability function. so i think we could leave those as is.

will look at KGD2...

[ValWood]

exception added for ILV5

[srengel]

i have removed the KGD2 annotation.