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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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MAtrix: tRNA metabolic process/ nucleocytoplasmic transport #2454

Open ValWood opened 5 years ago

ValWood commented 5 years ago

https://en.wikipedia.org/wiki/Cleavage_and_polyadenylation_specificity_factor

CPSF4 | Cleavage and polyadenylation specificity factor subunit 4 |   | mRNA export from nucleus |   | Reactome | Homo sapiens | TAS |   | zinc finger clipper -related pthr23102 | protein |   | Reactome:R-HSA-77594 | 20180419

I have never been sure if CPSF complex is part of export, or just an upstream process required export. I know the tail is important for export and mutants in CPSF block export but would we annotate this to export itself?

ValWood commented 5 years ago

acts_upstream_of ?

pgaudet commented 5 years ago

@deustp01

deustp01 commented 5 years ago

This is an issue of pathway / process boundaries, and the Reactome view, for better or worse, as laid out in the annotation of the whole pathway "Transport of Mature mRNA Derived from an Intronless Transcript" R-HSA-159231 is that R-HSA-77594 is one of its required parts.