Review annotations to protein heterodimerization activity (GO:0046982)

[vanaukenk]

Continuing on with review of the 'x-merization activity' terms, here are the annotations that need review for 'protein heterodimerization activity' (GO:0046982).

Reviews are organized below according to evidence code, with recommendations in the spreadsheet here:

https://docs.google.com/spreadsheets/d/1W2e7v-XFh8rBA6ETSuwz1uDJv3DPc4P7mU0eQ1ds_44

Full guidelines are available here in a Google doc:

https://docs.google.com/document/d/1JxzNwl1fr5Fj-IJy_Fo1lLfAlAQB8IxPDwwYKxIXBZo

Any questions, please add a comment to the ticket.

Please remember to mark the spreadsheet when you're done, so we can calculate accurate metrics for review efforts for the grant.

Thank you!

[vanaukenk]

IDA

Annotations to GO:0046982 (protein heterodimerization activity) and evidence code ECO:0000314 (IDA)

Issue: Need manual review to change to 'protein binding' (GO:0005515) with appropriate interaction id or accession in the With/From field:

UniProt - 145 CAFA - 18 MGI - 18 (none are to mouse proteins) AgBase - 12 FlyBase - 10 BHF-UCL - 8 HGNC -3 dictyBase - 3 EcoCyc - 2 RGD - 2 SGN - 2 TAIR - 2 ZFIN - 1

[vanaukenk]

IMP

Annotations to GO:0046982 (protein heterodimerization activity) and evidence code ECO:0000315 (IMP)

Issue: Need manual review to see if the annotations refer to the wild-type function and if a corresponding experimental annotation to the wild-type protein exists

CAFA - 17 UniProt - 10

[vanaukenk]

TAS

Annotations to GO:0046982 (protein heterodimerization activity) and evidence code ECO:0000304 (TAS)

Action: remove; if possible, check for or add corresponding experimental annotation

UniProt - 9 FlyBase - 5 ARUK-UCL - 4 GeneDB - 4 @uliboehme ParkinsonsUK-UCL - 4 AgBase - 2 HGNC - 1

[vanaukenk]

NAS

Annotations to GO:0046982 (protein heterodimerization activity) and evidence code ECO:0000303 (NAS)

Action: remove; if possible, check for or add corresponding experimental annotation

ParkinsonsUK-UCL - 8 UniProt - 7 FlyBase - 4 ARUK-UCL - 2 Zfin - 2 GeneDB - 4 TAIR - 1

[gthayman]

RGD done. Signed in, but unable to edit spreadsheet. Edit access (which I thought I had) rerequested.

[gthayman]

RGD changes recorded. Thanks Kimberly.

[vanaukenk]

Thanks @gthayman !

[uliboehme]

GeneDB/Plasmodium done. I was unable to edit the spreadsheet. The UniProt IDs listed in the spreadsheet are the same as the GeneDB IDs (PF3D7_0524000, PF3D7_0812400). Those 2 genes have been changed in the annotation database.

[pgaudet]

@uliboehme We should add you to the GO Google drive. Can you email go-hepldesk help-at-eneontology.org with the email you would like to use for this ?

Thanks, Pascale

[vanaukenk]

Thanks @uliboehme I updated the spreadsheet for now, but yes, please let us know what email you'd like to use for access to the GO's Google drive.

[pfey03]

Dicty is done, thanks!

[hdrabkin]

MGI done

[keseler]

The two EcoCyc annotations were removed some months ago. I don't have edit permission for the spreadsheet; could someone note the change?

[hattrill]

FB done

[tberardini]

@ebakker2 Can you please review the three TAIR annotations (see above)? Thanks.

[RLovering]

HGNC-UCL and BHF-UCL annotations all removed

[BarbaraCzub]

Hi @vanaukenk I am not able to edit the spreadsheet. You will have received a request to edit from my gmail account. Thanks, Barbara

[pgarmiri]

CAFA and UniProt-EBI annotation have been checked and actions recorded in the spreadsheet. There are still SWIS and SWIP annotations left that have been marked with a purple and light orange tag, respectively. Thanks, Penelope

[BarbaraCzub]

ParkinsonsUK-UCL done: 5 changed and 7 removed.

[BarbaraCzub]

ARUK-UCL done. All changed. cc @RLovering