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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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UniProtKB-KW:KW-0415 P40383 not karyogamy #2826

Closed ValWood closed 4 years ago

ValWood commented 4 years ago

This seems indirect

UniProtKB-KW:KW-0415 | S. pombe | P40383 | exo2 | karyogamy |   | indirect phenotype

phenotype only?

Also this part of the function summary may be out of date?

Acts as a microtubule-associated protein which interacts with cytoplasmic microtubules through beta-tubulin and promotes in vitro assembly of tubulin into microtubules. Associates with microtubule functions such as chromosome transmission, nuclear migration, and SPB duplication. Has also a role in G1 to S transition and is involved in nuclear fusion during karyogamy (By similarity).

as in fission yeast I dopn't think there is any evidence that exo1 is a MAP

ValWood commented 4 years ago

I think the karyogamy comes from S. cerevisiae anyway

and in pombe mating is normal

FYPO:0000760 | normal mating | exol-1::ura4 (disruption) | Microscopy |   | Szankasi P et al. (1995)

mah11 commented 4 years ago

hang on, is this about exo1 or exo2? The UniProt annotation says exo2 (which doesn't have a mating phenotype annotated, normal or abnormal).

sylvainpoux commented 4 years ago

Corrected. Note that I also simplified/modified function and added experimental evidence tags to the exonuclease activity. Thanks Sylvain

ValWood commented 4 years ago

Ah sorry was exo2, but the role in karyogamy is unreported and exo2 is required for vegetative growth so likely to have pleiotropic phenotypes.

karyogamy is from an S. cerevisiae phenotype (probably used to be a GO annotation,? ) now only has nuclear fusion during mating: absent