search

geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
BSD 3-Clause "New" or "Revised" License
34 stars 10 forks source link

4 entries for the same GP #2903

Closed ValWood closed 4 years ago

ValWood commented 4 years ago

@hattrill have you come across this?

Screenshot 2020-03-24 at 13 24 09

4 entries for the same gene product, EXP annotation look identical?

hattrill commented 4 years ago

Hi Val, This is because there are multiple FBgn:UniProtKB ids. When GOA imports annotations made to gene products, it propagates them to the UniProtKB id assoicated with this gene. Ideally, there would just be one swissprot id and any isoforms would be under them. There are various reasons why there might be multiple mappings: lots of trembls, proteoforms that can't be brought under one SP id, etc. When we make new annotations, we use the id from the ref set. Humans are lucky - most have just a 1:1 UniProtKB:gene as it all been reviewed, other species, such as D.mel, are a bit of a way off. But UniProt are chipping away at it.

ValWood commented 4 years ago

Ah OK, of course. I though all the models were 1:1 already ;)