gocentral
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18 years ago Logged In: YES user_id=436423
Group II intron splicing (GO::0000373) and nuclear mRNA splicing, via spliceosome (GO:0000398) are siblings (along with Group III intron splicing GO:0000374); the parent is 'RNA splicing, via transesterification reactions with bulged adenosine as nucleophile' (GO:0000377). You may prefer the grandparent 'RNA splicing, via transesterification reactions' (GO:0000375).
Background (stop reading if you aren't interested): We used to have a term 'mRNA splicing', but it's now obsolete because it turned out to represent a mishmash of different processes. Karen Christie at SGD went through and overhauled the RNA splicing process terms a while back (with input from others, especially Harold Drabkin at MGI), with the result that the terms are now organized by splicing mechanism rather than substrate. This makes sense for GO, since gene product involvement correlates with mechanism.
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Original comment by: mah11
This means that the Uniprot keyword 'splicing' cannot map to mRNA splicing (but this doesn't exitst?)
anyway it needs to map to a common parent of
nuclear mRNA splicing, via spliceosome
AND
Group II intron splicing
becasue the Uniprot keyword mRNA splicing covers both.
Cheers
Val
Hi Val,
I've just heard back from Geneva and Amos has deleted the last sentence 'This process occurs in the NUCLEUS before the fuctional mRNA is sent to the cytoplasm." in the 'mRNA splicing' KW, so this should solve the problem ie. shouldn't be mapped to 'NUCLEAR mRNA splicing, via spliceosome' any more...
Thanks, Kati
Valerie Wood wrote:
> > Hi > S. pombe protein p87149 > is a mitochodrial protein involed in the splicing of group II introns (RNA proccessing) > > however it has KW mRNA processing and mRNA splicing. Can these be removed as they are giving mappings to > nuclear mRNA splicing, via spliceosome
Reported by: ValWood
Original Ticket: "geneontology/annotation-issues/294":https://sourceforge.net/p/geneontology/annotation-issues/294