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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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NTNU GON4L not a dbTF #2990

Closed RLovering closed 4 years ago

RLovering commented 4 years ago

Hi Marcio I don't think this protein binds DNA. PMID: 29615614 states in discussion:Because Gon4l does not bind DNA directly, we predict that Gon4l-enriched genomic loci are direct targets of chromatin modifying protein complexes with which Gon4l associates[36]. Ref 36 is https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093903/ which also does not suggest DNA binding capacity of GON4L. In addiiton both Lambert and Tripathi lists both state that this is not a dbTF. Thanks Ruth

pgaudet commented 4 years ago

@mlacencio

mlacencio commented 4 years ago

@pgaudet and @RLovering, Q3T8J9/GON4L removed! HT-SELEX also shows no binding of GON4L to any DNA specific sequence.

RLovering commented 4 years ago

This is great, thank you so much Ruth