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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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SKOR1 and SKOR2 dbTFs not corepressors #2998

Closed RLovering closed 4 years ago

RLovering commented 4 years ago

Hi

WRT InterPro:IPR028762

sorry to bother you but in the transcription review it has been agreed that SKOR1 and SKOR2 and probably SKI and SKIL are dbTFs. If you have evidence that these do not bind DNA at all then please let me know. SKOR1 and SKOR2 have been shown by Yin et al by HT-SELEX to bind DNA although SKI and SKIL do not appear to bind DNA alone. But if you agree with this decision please could you remove the mapping to the GO term transcription corepressor activity (GO:0003714) from InterPro:IPR028762

https://github.com/geneontology/go-annotation/issues/2983

P84550 | SKOR1 Q2VWA4 | SKOR2

many thanks Ruth

mlacencio commented 4 years ago

@RLovering!

Nice that we have reached an agreement about these DbTFs. Regarding the deletion of the mapping mention by you, I am afraid to say that I have no idea how to do it. I have no access to the GO:0003714 annotation in Protein2GO that is assigned to REFG.

Best,

Marcio

RLovering commented 4 years ago

Hi Marcio sorry I meant this to be directed to InterPro. I have edited the request to make this clearer. Best Ruth

pgaudet commented 4 years ago

@EBI-Hsinyu @typhainepl @happy-lorna

Please do the same for IPR028376 (SKOR2). IPR028762 mentioned in the first comment corresponds to SKOR1.

Thanks, Pascale

EBI-Hsinyu commented 4 years ago

Hi Ruth, Thank you for this. Could you send me the reference (from Yin et al), please? So, I can update these entries. Regards, Hsin-Yu

RLovering commented 4 years ago

Hi So sorry to have missed this information. Please see https://europepmc.org/article/MED/28473536 Table S2 (https://science.sciencemag.org/highwire/filestream/693922/field_highwire_adjunct_files/1/aaj2239_Yin_SM_tables_S1-S6.xlsx) of the paper. Thanks Ruth

EBI-Hsinyu commented 4 years ago

Thank you! Hsin-Yu

EBI-Hsinyu commented 4 years ago

I have deleted this term GO:0003714 in both entries. Hsin-Yu

RLovering commented 4 years ago

wonderful thank you so much Ruth