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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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IPR036051 should not include nucleic acid binding (GO:0003676) #3155

Closed RLovering closed 4 years ago

RLovering commented 4 years ago

Hi

the KRAB domain superfamily record IPR036051 https://www.ebi.ac.uk/interpro/entry/InterPro/IPR036051/ and the record IPR001909 should not include the GO term nucleic acid binding (GO:0003676) The record actually states: The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors.

A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model.

The KRAB domain functions as a transcriptional repressor when tethered to the template DNA by a DNA-binding domain. A sequence of 45 amino acids in the KRAB A subdomain has been shown to be necessary and sufficient for transcriptional repression.

Best

Ruth

sarach06 commented 4 years ago

Hi Ruth, Thank you very much. I have removed the term from those entries. The changes will be seen in the next release (InterPro 81.0). Best regards, Sara

pgaudet commented 4 years ago

Thanks!