search

geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
BSD 3-Clause "New" or "Revised" License
34 stars 10 forks source link

PTN000950370 (PTHR12119) #3635

Closed sjm41 closed 3 years ago

sjm41 commented 3 years ago

PTN000950370 adds "ubiquinol-cytochrome-c reductase activity CONTRIBUTES_TO)" to members of the UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C (PTHR12119) family.

But those proteins are not one of the 3 catalytic (redox) subunits of the complex (e.g. PMID: 10966481, PMID: 23201476), so I think this GO term should be removed.

Source annotations are:

  1. PTN000950391 (YEAST|SGD=S000003702|UniProtKB=P08525) @srengel IMP from PMID: 8394810 ("A region of the C-terminal part of the 11-kDa subunit of ubiquinol-cytochrome-c oxidoreductase of the yeast Saccharomyces cerevisiae contributes to the structure of the Qout reaction domain")

  2. PTN000251842 (SCHPO|PomBase=SPAC1782.07|UniProtKB=P50523) @ValWood IGI from PMID: 9395324 ("The role of subunit VIII in the structural stability of the bc1 complex from Saccharomyces cerevisiae studied using hybrid complexes")

ValWood commented 3 years ago

PomBase MF annotations removed. Do we know what the non-redox subunits do?

sjm41 commented 3 years ago

The title of the two source papers suggest a role in 'structural stability' of the complex.

PMID: 23201476 (Xia et al 2013) says "The subunit composition of bc1 complexes varies significantly... to as many as eleven subunits in human and bovine mitochondria. All bc1 complexes contain three redox subunits: cyt b; cyt c1; and the iron sulfur protein (ISP). All additional subunits, referred to as supernumerary subunits, have no well-established cellular function except for the subunits core-1 and core-2 in plants, which are metalloproteases, and thus are believed to contribute to the increased stability of these complexes."

marcfeuermann commented 3 years ago

Corrected at the PAINT level. Waiting for SGD feedback by @srengel to close this ticket.

srengel commented 3 years ago

i have removed the SGD annotation in P2GO just now.

marcfeuermann commented 3 years ago

Cool, thanks :-)