IPR024629 non ribosomal annotation appear to be phenotype/readout

geneontology / go-annotation

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IPR024629 non ribosomal annotation appear to be phenotype/readout #3836

Open ValWood opened 3 years ago

ValWood commented 3 years ago

InterPro ID / label

IPR024629
Example sequences with problematic annotation (ID + gene/protein name):
Description of issue

DNA strand exchange activity DNA recombination | IEA with IPR024629 | GO_REF:0000002 | 137 mitochondrial genome maintenance | IEA with IPR024629

seem out of date, old papers based on https://www.yeastgenome.org/locus/S000002704

At least these look like indirect phenotypes. May be correct but probably not safe to map.

EBI-Hsinyu commented 3 years ago

Hi Val,

Thank you for the e-mail. Besides the paper mentioned in the abstract (2019, PMID: 30931958), I found a few more papers describing Mhr1 as a mitochondrial recombinase. I think the InterPro abstract is more updated than SGD in this case.

Heteroduplex joint formation free of net topological change by Mhr1, a mitochondrial recombinase (PMID: 19193646) Recombination-dependent mtDNA partitioning: in vivo role of Mhr1p to promote pairing of homologous DNA (PMID: 12198175) Prevention of mitochondrial genomic instability in yeast by the mitochondrial recombinase Mhr1 (PMID: 30931958)

Regards, Hsin-Yu

ValWood commented 3 years ago

Hi,

I think it is now considered to be a mitochondrial ribosomal protein (L67) https://www.yeastgenome.org/reference/S000175407 and the other processes would be indirect phenotypes (one is curated as IDA, but I do not immediately see this).

If you keep this one open I will check with a mitochondrial expert at some point and get back to you.

Val

EBI-Hsinyu commented 3 years ago

Thanks! That will be great!

Hsin-Yu