InterPro:IPR013822 inc mapping

[gocentral]

InterPro:IPR013822

maps to signal recognition particle, endoplasmic reticulum targeting (the term for endoplasmic reticulum SRP)

This is the SRP receptor complex subunit (not the SRP itself) and should be mapped to

signal recognition particle receptor complex GO:0005785

Reported by: ValWood

Original Ticket: "geneontology/annotation-issues/419":https://sourceforge.net/p/geneontology/annotation-issues/419

[gocentral]

• labels: --> InterPro mapping
• milestone: --> InterPro
• assigned_to: nobody --> orchard

Original comment by: mah11

[gocentral]

Logged In: YES user_id=545117 Originator: NO

No - according to the abstract, hierarchy of entries and UniProt entries that it hits, its a domain within the 54kDa subunit of the particle, not the receptor.

Sandra

Original comment by: orchard

[gocentral]

• status: open --> closed

Original comment by: orchard

[gocentral]

Logged In: YES user_id=516865 Originator: YES

Hi Sandra,

This one still seems a bit odd. I looked a bit more closely and we were probably looking at different entries. I seem to have 3 pombe entries with this Interpro domain: Uniprot O74846 Exocyst complex component sec6. O43032 SPBC3B9.03 protein (this is ignal recognition particle receptor alpha subunit Srp101 ) UniProt P21565 Signal recognition particle 54 kDa protein homolog (SRP54).

so it seems to be present in the particle, the receptor and an exocyst subunit? sorry, I should have been more thorough.

Val

Original comment by: ValWood

[gocentral]

Logged In: YES user_id=545117 Originator: NO

Hi

When you've decided what it really is, let me know if you want the status changed for any misleading signatures.

Sandra

Original comment by: orchard

[gocentral]

Logged In: YES user_id=516865 Originator: YES

I don't know.

To me, it looks as though it is not specific for signal recognition particle, it is also present in the receptor (for pombe O43032, and cerevisiae P32916) .In addition it is present in the S. pombe O74846 Exocyst complex component sec6.

I guess, if the intention is that this region is defined as being specific for the SRP then the above are false positives but the liklihood is that this domin hits many other sequences outside of this orthologous group. Perhaps it should have its mappings changed to just GTP binding? At present the mappings are incorrect but this isn't a pombe specific problem.

Original comment by: ValWood