IPR001222 and IPR006289 (for TFIIS)

geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.

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IPR001222 and IPR006289 (for TFIIS) #442

Closed gocentral closed 9 years ago

gocentral commented 17 years ago

Hi,

I think the association of these two InterPro domains to 'DNA binding' may be incorrect. As far as I'm aware, TFIIS proteins are only known to bind to RNA polymerase II.

thanks,

-Karen

Reported by: krchristie

Original Ticket: "geneontology/annotation-issues/442":https://sourceforge.net/p/geneontology/annotation-issues/442

gocentral commented 17 years ago

labels: --> InterPro mapping
milestone: --> InterPro
assigned_to: nobody --> orchard

Original comment by: mah11

gocentral commented 17 years ago

Logged In: YES user_id=545117 Originator: NO

Changed to nucleic acid binding

Sandra

Original comment by: orchard

gocentral commented 17 years ago

status: open --> closed

Original comment by: orchard

gocentral commented 17 years ago

Logged In: YES user_id=473890 Originator: YES

Hi Sandra,

What's the evidence that TFIIS proteins bind to nucleic acid at all?

The crystal structure of TFIIS with RNA pol II shows that it interacts with the polymerase and sticks a long narrow domain into a hole in the polymerase that gives it access to the catalytic site, but I've never seen any evidence that TFIIS binds nucleic acids, of any kind, on its own.

thanks,

-Karen

Original comment by: krchristie