PTN000118612

[ValWood]

• PTHR ID & PTN node:

PTN000118612

• Sequences with problematic annotation (ID + gene/protein name):

https://www.pombase.org/gene/SPAC139.01c

• Type of Issue: Erroneous source or erroneous propagation, or other issue

PROPAGATION mkt1 is post-transcriptional RNA stability regulator Mkt1

it is slightly related to exo1 https://www.pombase.org/gene_subset/interpro:IPR006085

and could be a nuclease, (it has a nuclease domain).

However, these annotations can't be transferred:

GO:0035312
5'-3' DNA exonuclease activity IBA with Q9UQ84 , PTN000118621 , exo1 , S000002671

GO:0017108
5'-flap endonuclease activity IBA with Q17RS7 , locus:2025447 , FBgn0263831 , PTN000118612 , rad2 , S000005559 , S000001596 , locus:2099463 , P39748

GO:0000729
DNA double-strand break processing IBA with PTN000871648 , exo1 , S000005559

GO:0006310
DNA recombination IBA with Q9UQ84 , S000005559 , PTN000118621 , MGI:1349427

GO:0006298
mismatch repair IBA with exo1 , S000005559 , Q9UQ84 , PTN000118621

It is more closely related to this protein: https://www.uniprot.org/uniprotkb/Q587E3/entry

There is a bit of data in fission yeast https://www.pombase.org/reference/PMID:31822915

• Add the label 'high priority' if needed. Generally high priority issues affect a lot of proteins, and annotations are incorrect (as opposed to just imprecise).

[marcfeuermann]

This is a nice case of ancient duplication event in fungi with gain/loss of function. Annotation has been corrected accordingly.