PTN000567094 / PTN000314659 / PTN000313715

[sjm41]

• PTHR ID & PTN node: PTN000567094 (RNA-BINDING MOTIF PROTEIN, X-LINKED 2 (PTHR45880) PTN000314659 (PRE-MRNA-SPLICING FACTOR ISY1 (PTHR13021)) PTN000313715 (PRE-MRNA SPLICING FACTOR-RELATED (PTHR13007))

• Type of Issue: Erroneous source or erroneous propagation, or other issue erroneous source

These three nodes add:

• "contributes_to first spliceosomal transesterification activity" to human RBMX2 / yeast IST3 orthologs
• "contributes_to first spliceosomal transesterification activity" to human ISY1 / yeast ISY1 orthologs
• "contributes_to second spliceosomal transesterification activity" to human PRPF18 / yeast PRP18 orthologs

Although those proteins are components of spliceosomal complexes, they are not the catalytic subunits so I think those annotations should be removed from each node.

E.g. Fig2B of "The spliceosome: design principles of a dynamic RNP machine." (PMID: 19239890) shows that PRP2 catalyses the first reaction and PRP16/PRP22 catalyses the second reaction. That review also states "Eight evolutionarily conserved DExD/H-type RNA-dependent ATPases/helicases act at specific steps of the splicing cycle to catalyze RNA-RNA rearrangements and RNP remodeling events. These enzymes include Sub2 (UAP56 in humans), Prp5, Prp28, Brr2, Prp2, Prp16, Prp22, and Prp43 (with Brr2 and Prp22 acting at more than one step in the cycle). "

[marcfeuermann]

The annotations have all been removed.

[sjm41]

Thanks!