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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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PTN001270476 #4563

Closed sjm41 closed 1 year ago

sjm41 commented 1 year ago

Not totally sure, but I think this PAINT annotation might need tweaking. Currently it adds these two very specific MF terms to all members of the family: diacylglycerol O-acyltransferase activity (= EC:2.3.1.20) long-chain-alcohol O-fatty-acyltransferase activity (= EC:2.3.1.75)

But the source annotations only come from bacteria and plants, and there's not much overlap between the annotated genes:

diacylglycerol O-acyltransferase activity: TAIR:locus:2169175 Wax ester synthase/diacylglycerol acyltransferase 1 Arabidopsis thaliana UniProtKB:P9WKB5 Putative diacyglycerol O-acyltransferase Rv2285 Mycobacterium tuberculosis UniProtKB:P9WKB9 Putative diacyglycerol O-acyltransferase Rv1760 Mycobacterium tuberculosis UniProtKB:P9WKC3 Probable diacyglycerol O-acyltransferase Tgs4 Mycobacterium tuberculosis UniProtKB:P9WKC5 Probable diacyglycerol O-acyltransferase tgs3 Mycobacterium tuberculosis UniProtKB:P9WKC7 Probable diacyglycerol O-acyltransferase tgs2 Mycobacterium tuberculosis UniProtKB:P9WKC9 Probable diacyglycerol O-acyltransferase tgs1 Mycobacterium tuberculosis

long-chain-alcohol O-fatty-acyltransferase activity: TAIR:locus:2169175 Wax ester synthase/diacylglycerol acyltransferase 1 Arabidopsis thaliana TAIR:locus:2082936 Wax ester synthase/diacylglycerol acyltransferase 6 Arabidopsis thaliana TAIR:locus:505006610 Wax ester synthase/diacylglycerol acyltransferase 7 Arabidopsis thaliana UniProtKB:P9WKA5 Putative diacyglycerol O-acyltransferase Rv3740c Mycobacterium tuberculosis UniProtKB:P9WKA7 Putative diacyglycerol O-acyltransferase Rv3480c Mycobacterium tuberculosis UniProtKB:P9WKC9 Probable diacyglycerol O-acyltransferase tgs1 Mycobacterium tuberculosis

Might be better to PAINT with a single MF to a shared parent term, ie. O-acyltransferase activity (GO:0008374)?

What do you think?

marcfeuermann commented 1 year ago

Indeed it might be safer. Done.

sjm41 commented 1 year ago

Thanks Marc!