PTN004606439 false positive for cytosolic ribosome

ValWood commented 1 year ago

PTHR ID & PTN node:

GO:0022625
cytosolic large ribosomal subunit IBA with S000003103 , P62424 , S000001025 , 620497 , MGI:1343877 , P62906 , S000003968 , PTN004606439 , S000006141 , 1307586 , MGI:1353472 Gaudet P et al. (2011) 88

Sequences with problematic annotation (ID + gene/protein name):

https://www.pombase.org/gene/SPAC1782.10c box H/ACA snoRNP complex subunit Nhp2

Type of Issue: Erroneous source or erroneous propagation, or other issue

Erroneous propagation NHP2 is yeast ortholog (SGD:S000002367)

Add the label 'high priority' if needed. Generally high priority issues affect a lot of proteins, and annotations are incorrect (as opposed to just imprecise).

ValWood commented 1 year ago

This is quite a big panther family, other inference issues (with correct S. cerevisiae orthologs)

https://www.pombase.org/gene/SPAC607.03c U3 snoRNP-associated protein Snu13 The yeast ortholog is SGD:S000000752

https://www.pombase.org/gene/SPAC8F11.04 U3 snoRNP-associated protein Cic1/Utp30 family SGD:S000001768 SGD:S000001094

https://www.pombase.org/gene/SPCC306.07c U3 snoRNP-associated protein Cic1/Utp30 family SGD:S000001768 SGD:S000001094

marcfeuermann commented 11 months ago

The whole annotation for this family has been reviewed. Several terms were over-propagated.

ValWood commented 7 months ago

This is recurring, see https://www.ebi.ac.uk/QuickGO/annotations?geneProductId=Q9P7H0&aspect=cellular_component cytosolic large ribosomal subunit

marcfeuermann commented 7 months ago

See https://github.com/geneontology/go-annotation/issues/5139

geneontology / go-annotation

PTN004606439 false positive for cytosolic ribosome #4786