Review annotations to GO:0019054 modulation by virus of host process - immune sytem perturbation terms

[pgaudet]

GO:0039699 | viral mRNA cap methylation GO:0099016 | evasion by virus of DNA end degradation GO:0019049 | virus-mediated perturbation of host defense response GO:0075528 | perturbation by virus of host immune response GO:0039503 | suppression by virus of host innate immune response GO:0039504 | suppression by virus of host adaptive immune response GO:0039573 | suppression by virus of host complement activation GO:0039673 | evasion by virus of host dendritic cell activity GO:0039671 | evasion by virus of host natural killer cell activity GO:0099018 | evasion by virus of host restriction-modification system GO:0098672 | inhibition of host CRISPR-cas system by virus

Annotations are here: https://docs.google.com/spreadsheets/d/1bdHnQ-00fhRVZIThWdhSUYYxbxgYAF_WYyx1eGmeDgI/edit#gid=0

• 10 CACAO
• 35 UniProt
• 4 HAMAP
• 5 UniRules
• 12 InterPro

[RLovering]

Hi Pascale

UCL has 11 annotations to child terms https://www.ebi.ac.uk/QuickGO/annotations?assignedBy=ARUK-UCL,Alzheimers_University_of_Toronto,BHF-UCL,HGNC-UCL,ParkinsonsUK-UCL,SynGO-UCL&goId=GO:0071507,GO:0030580,GO:1990887,GO:0004395,GO:0044595,GO:0019054,GO:0052559,GO:1990216,GO:0061542&goUsageRelationships=is_a,part_of,occurs_in,regulates&goUsage=descendants

Term ID	Term name	comment
GO:0039656	modulation by virus of host gene expression
GO:1904188	negative regulation of transformation of host cell by virus
GO:1904187	regulation of transformation of host cell by virus
GO:1904189	positive regulation of transformation of host cell by virus
GO:0019050	suppression by virus of host apoptotic process
GO:0019056	modulation by virus of host transcription
GO:0046775	suppression by virus of host cytokine production

Will these child terms be obsoleted too? Thanks Ruth

[pgaudet]

Hi Ruth,

Here you go:

Term ID	Term name	To be merged into the more general 'symbiont' term
GO:0039656	modulation by virus of host gene expression	yes
GO:1904188	negative regulation of transformation of host cell by virus	no, will remain
GO:1904187	regulation of transformation of host cell by virus	no, will remain
GO:1904189	positive regulation of transformation of host cell by virus	no, will remain
GO:0019050	suppression by virus of host apoptotic process	yes
GO:0019056	modulation by virus of host transcription	yes
GO:0046775	suppression by virus of host cytokine production	yes

Note that only viral genes should be annotated to these processes.

Thanks, Pascale

[RLovering]

great, I think I have revised the UCL ones and these are all to viruses

[pgaudet]

The only term I will fix for now is suppression by virus of host complement activation; obsolete & replace by GO:0042784 symbiont-mediated suppression of host complement activation 1 UniProt annotation, i KW, no action needed