Closed ValWood closed 5 months ago
Hello Val. Is this the issue where this "gene expression" GO term is not appropriate because it proteins has a QC role in transcription, but it does not perform transcription itself?
Ap[ologies, gene_expression is OK. This is QC for translation (not transcription), but this is part_of gene_expression
Actually this is the problem annotation: Probably based on historical annotation
UniProtKB:O60072 | slh1 | involved_in | GO:0090304 nucleic acid metabolic process | ECO:0000256 IEA | GO_REF:0000117 | ARBA:ARBA00026771 |
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@Antonialock, would it be possible to review the GO term GO:0090304 (nucleic acid metabolic process) in O60072, to see if this still should be in this entry, please? Thank you
@PedroRaposo I cannot see that annotation in quickgo? https://www.ebi.ac.uk/QuickGO/annotations?geneProductId=O60072
@PedroRaposo do you have a protocol for reviewing ARBA annotations? Or a page to see how it is derived (I think there is one but I cannot find it?)
It is possible it comes from a kw annotation "transcription regulation" to the higher orthologs Q8N3C0 E9PZJ8 F1LPQ2 E1BNG3 E7F8F4 F1NTD6 Q54G57.
I have replaced this keyword with translation regulation.
humn protein also seems to be involved in DNA repair
I don't think its really regulation of ribosome assembly, its involved in the rescue of stalled ribosomes?
OK, it does seem to be multifunctional... at least the earlier work, although not annotated from many sources does not seem to be overturned
I removed that keyword too. Hopefully this should fix the ARBA issue in any case
UniProtKB:O60072 slh1 involved_in GO:0010467 gene expression ECO:0000256 IEA GO_REF:0000117
ARBA:ARBA00028330 284812 Schizosaccharomyces pombe (strain 972 / ATCC 24843)
UniProtKB-KW:KW-0469 284812 Schizosaccharomyces pombe (strain 972 / ATCC 24843)
https://www.ebi.ac.uk/QuickGO/annotations?geneProductId=O60072
See https://github.com/geneontology/go-annotation/issues/4895 for a detailed description of the issue