ARBA:ARBA00028330

[ValWood]

• ARBA rule (ID and label):

UniProtKB:O60072 slh1 involved_in GO:0010467 gene expression ECO:0000256 IEA GO_REF:0000117
ARBA:ARBA00028330 284812 Schizosaccharomyces pombe (strain 972 / ATCC 24843)

UniProtKB-KW:KW-0469 284812 Schizosaccharomyces pombe (strain 972 / ATCC 24843)

• Sequences with problematic annotation (ID + gene/protein name):

https://www.ebi.ac.uk/QuickGO/annotations?geneProductId=O60072

• Description of issue

See https://github.com/geneontology/go-annotation/issues/4895 for a detailed description of the issue

[PedroRaposo]

Hello Val. Is this the issue where this "gene expression" GO term is not appropriate because it proteins has a QC role in transcription, but it does not perform transcription itself?

[ValWood]

Ap[ologies, gene_expression is OK. This is QC for translation (not transcription), but this is part_of gene_expression

[ValWood]

Actually this is the problem annotation: Probably based on historical annotation

UniProtKB:O60072	slh1	involved_in	GO:0090304    nucleic acid metabolic process	ECO:0000256   IEA	GO_REF:0000117	ARBA:ARBA00026771

[PedroRaposo]

@Antonialock, would it be possible to review the GO term GO:0090304 (nucleic acid metabolic process) in O60072, to see if this still should be in this entry, please? Thank you

[Antonialock]

@PedroRaposo I cannot see that annotation in quickgo? https://www.ebi.ac.uk/QuickGO/annotations?geneProductId=O60072

[Antonialock]

@PedroRaposo do you have a protocol for reviewing ARBA annotations? Or a page to see how it is derived (I think there is one but I cannot find it?)

It is possible it comes from a kw annotation "transcription regulation" to the higher orthologs Q8N3C0 E9PZJ8 F1LPQ2 E1BNG3 E7F8F4 F1NTD6 Q54G57.

I have replaced this keyword with translation regulation.

[Antonialock]

humn protein also seems to be involved in DNA repair

[ValWood]

I don't think its really regulation of ribosome assembly, its involved in the rescue of stalled ribosomes?

[ValWood]

OK, it does seem to be multifunctional... at least the earlier work, although not annotated from many sources does not seem to be overturned

[Antonialock]

I removed that keyword too. Hopefully this should fix the ARBA issue in any case