Closed ValWood closed 8 months ago
Thanks, I'm working on this now. On a quick look I wonder why atxn10 is not annotated to cytokinesis
21857149 : Knockdown of ATXN10 with siRNA in HeLa cells results in cytokinesis defects-multinucleation, which are rescued by wild-type Ataxin-10, but not the phosphor-deficient 2A mutant.
25666058: Taken together, we propose a model that Aurora B phosphorylates Ataxin-10 at S12 to promote the interaction between Ataxin-10 and Plk1 in cytokinesis. These findings identify an Aurora B-dependent mechanism that implicates Ataxin-10 in cytokinesis.
34970537: Atxn10 is a gene known for its role in cytokinesis
I'll curate these papers but if you object to the process being added and propagated then let me know!
Defects in cytokinesis can come from lots of processes,
transcription/translation/ transport/ DNA replication/ DNA repair (due to checkpoint stuff ups) https://www.pombase.org/results/from/id/9e72c5d1-00aa-4da8-833c-5f700ccd3c09
so unless there is more than this phenotype I'd be cautious to make a GO annotation. I doubt that this would have been missed for fission yeast (which has ATXN10 ortholog)
Fission yeast is inviable but not reported to have a terminal cytokinesis phenotype (elongated/multinucleate/aseptate).
It could be "regulation of cytokinesis" from interaction with Aurora, so maybe a connection to coordinate chromosome segregation with cytokinses). It would be good to know i) where it is observed, presumably centrosome, in which case it could be OK to "regulation of..."
In one of the papers they saw it in the region of the cilium base and centriole.
I have removed the keywords which should be integrated in the next week or so...mappings will disappear in "time"
Keywords Biological process #Amino-acid biosynthesis #Threonine biosynthesis
https://www.uniprot.org/uniprotkb/P25355/entry