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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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Incorrect UniProt KW mapping: KW-0028 & KW-0791 seem to be out of data for x P25355 #4962

Closed ValWood closed 8 months ago

ValWood commented 9 months ago

Keywords Biological process #Amino-acid biosynthesis #Threonine biosynthesis

https://www.uniprot.org/uniprotkb/P25355/entry

Antonialock commented 8 months ago

Thanks, I'm working on this now. On a quick look I wonder why atxn10 is not annotated to cytokinesis

21857149 : Knockdown of ATXN10 with siRNA in HeLa cells results in cytokinesis defects-multinucleation, which are rescued by wild-type Ataxin-10, but not the phosphor-deficient 2A mutant.

25666058: Taken together, we propose a model that Aurora B phosphorylates Ataxin-10 at S12 to promote the interaction between Ataxin-10 and Plk1 in cytokinesis. These findings identify an Aurora B-dependent mechanism that implicates Ataxin-10 in cytokinesis.

34970537: Atxn10 is a gene known for its role in cytokinesis

Antonialock commented 8 months ago

I'll curate these papers but if you object to the process being added and propagated then let me know!

ValWood commented 8 months ago

Defects in cytokinesis can come from lots of processes,

transcription/translation/ transport/ DNA replication/ DNA repair (due to checkpoint stuff ups) https://www.pombase.org/results/from/id/9e72c5d1-00aa-4da8-833c-5f700ccd3c09

so unless there is more than this phenotype I'd be cautious to make a GO annotation. I doubt that this would have been missed for fission yeast (which has ATXN10 ortholog)

ValWood commented 8 months ago

Fission yeast is inviable but not reported to have a terminal cytokinesis phenotype (elongated/multinucleate/aseptate).

ValWood commented 8 months ago

It could be "regulation of cytokinesis" from interaction with Aurora, so maybe a connection to coordinate chromosome segregation with cytokinses). It would be good to know i) where it is observed, presumably centrosome, in which case it could be OK to "regulation of..."

Antonialock commented 8 months ago

In one of the papers they saw it in the region of the cilium base and centriole.

I have removed the keywords which should be integrated in the next week or so...mappings will disappear in "time"