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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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TreeGrafter issue (And PAINT) PANTHER:PTHR11208:SF45 #5013

Open ValWood opened 6 months ago

ValWood commented 6 months ago

bpb1 Branchpoint-bridging protein

UniProtKB:O74555 | bpb1 | involved_in | GO:0048024    regulation of mRNA splicing, via spliceosome | ECO:0000318   IBA | GO_REF:0000033 | FB:FBgn0022984 more... | 284812 Schizosaccharomyces pombe (strain 972 / ATCC 24843) | GO_Central |  

UniProtKB:O74555 | bpb1 | involved_in | GO:0048024    regulation of mRNA splicing, via spliceosome | ECO:0007826   IEA GO_REF:0000118 | PANTHER:PTHR11208:SF45 | 284812 Schizosaccharomyces pombe (strain 972 / ATCC 24843) | TreeGrafter

@hattrill This should be
GO:0045292 mRNA cis splicing, via spliceosome rather than regulation

hattrill commented 6 months ago

Hi @ValWood I think that the bigger issue here is that these two FBgns are not the best predicted orthologs for bpb1.

SF1 Splicing factor 1 is the best the "hit" for bpb1 which is annotated with mRNA splicing, via spliceosome (IC, ISS), the genes used by treeGr for propagtion are:

FB:FBgn0022984 qkr58E-3 OR FB:FBgn0264491 how are RNA binding proteins, but haven't been characterised as part of the spliceosome, so I cannot change these to GO:0045292 mRNA cis splicing, via spliceosome

I would say that the similarity is not sufficient to propagate to bpb1.

To me this looks like a "selection" issue for Panther/TreeG.