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geneontology / go-annotation

This repository hosts the tracker for issues pertaining to GO annotations.
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Incorrect Unirule mapping: UR000106116 / UR000106136/ UR000106401/ UR000106116 for Ermes complex #5091

Open ValWood opened 6 months ago

ValWood commented 6 months ago

UniProt UniRule (ID and label):

Ermes complex GO:0000002 | mitochondrial genome maintenance | IEA with UR000106116 | GO_REF:0000104

Sequences with problematic annotation (ID + gene/protein name):

Description of issue

This seems to be a phenotype (the GO term is a bit "phenotypey" anyway, I'm not sure it should exist, but it is definitely indirect here).

This is the current state of the art on Ermes: https://pubmed.ncbi.nlm.nih.gov/37857894/

(i.e problems with the nucleoid are downstream problems from perturbing membrane composition, not an evolved mechanism to maintain the genome)

ValWood commented 6 months ago

The protein insertion annotation should also be reviewed for ERMES

GO:0045040 | protein insertion into mitochondrial outer membrane | IEA with UR000106116 | GO_REF:0000104 (https://www.pombase.org/reference/GO_REF:0000104)

unless they are also a member of SAM complex (some subunits are shared)

ValWood commented 6 months ago

It is possible that ERMES also imports proteins into mitochondrion from ER. I can't find any information to support this, but if you have the specific annotations that the inferences were derived from, I can double-check.