Antonialock
commented
1 month ago I could remove all the uniprot and cafa ones - for all those annotations, cyclosporin was binding targets it inhibits. Some annotations were new (in the last few years), perhaps it would be ok to obsolete the term? It looks like all the annotated proteins are targets inhibited by cyclosporin - I don't think any of them represent (for example) immune system/detoxification proteins that bind the drug to mount a response/catabolize the drug.
these 11 annotations (of 34) are left:
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UniProtKB:E9AFV2 | CYP40 | enables | GO:0016018 cyclosporin A binding | ECO:0000314 IDA | PMID:20614016 | | 5664 Leishmania major | GeneDB -- | -- | -- | -- | -- | -- | -- | -- | -- UniProtKB:P10111 | Ppia | enables | GO:0016018 cyclosporin A binding | ECO:0000314 IDA | PMID:19832699 | | 10116 Rattus norvegicus | RGD UniProtKB:P14832 | CPR1 | enables | GO:0016018 cyclosporin A binding | ECO:0000315 IMP | PMID:7515500 | | 559292 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | SGD UniProtKB:P15425 | ninaA | enables | GO:0016018 cyclosporin A binding | ECO:0000315 IMP | PMID:2493138 | | 7227 Drosophila melanogaster | FlyBase UniProtKB:P21568 | CYP | enables | GO:0016018 cyclosporin A binding | ECO:0000314 IDA | PMID:1702215 | | 4081 Solanum lycopersicum | AgBase UniProtKB:P21569 | CYP | enables | GO:0016018 cyclosporin A binding | ECO:0000315 IMP | PMID:8645184 | | 4577 Zea mays | AgBase UniProtKB:P29117 | Ppif | enables | GO:0016018 cyclosporin A binding | ECO:0000314 IDA | PMID:1599421 | | 10116 Rattus norvegicus | RGD UniProtKB:Q10724 | Q10724 | enables | GO:0016018 cyclosporin A binding | ECO:0000314 IDA | PMID:8645184 | | 4577 Zea mays | AgBase UniProtKB:Q4QJ67 | CYP2 | enables | GO:0016018 cyclosporin A binding | ECO:0000314 IDA | PMID:19923714 | | 5664 Leishmania major | GeneDB UniProtKB:Q6DGG0 | Ppid | enables | GO:0016018 cyclosporin A binding | ECO:0000314 IDA | PMID:19832699 | | 10116 Rattus norvegicus | RGD UniProtKB:Q76NN7 | PF3D7_0322000 | enables | GO:0016018 cyclosporin A binding | ECO:0000314 IDA | PMID:9716503 | | 36329 Plasmodium falciparum (isolate 3D7) | GeneDB
I have a few annotations for cyclosporin A binding from lots of sources. It seems odd since cyclosporin is a compound isolated from soil fungus and used as an immunosuppressive drug. Presumably, this binding is not physiologically relevant for most organisms? I am going to block the GO term for PomBase, but I don't like doing this unless I report it...
see above
Type of Issue: Erroneous source or erroneous propagation, or other issue
Add the label 'high priority' if needed. Generally high priority issues affect a lot of proteins, and annotations are incorrect (as opposed to just imprecise).