Incorrect UniProt KW mapping: IEA with KW-0457

[ValWood]

• UniProt KeyWord (ID and label):

GO:0009085 | lysine biosynthetic process | IEA with KW-0457

• Sequences with problematic annotation (ID + gene/protein name):

https://www.pombase.org/gene/SPCC1827.06c

GO:0004073 | aspartate-semialdehyde dehydrogenase activity

• Description of issue

aspartate-semialdehyde dehydrogenase is involved in the common pathways of methionine and threonine biosynthesis. isoleucine and other branched-chain amino acids are synthesised from threonine, but this seems quite indirect

[Antonialock]

ah https://link.springer.com/article/10.1385/CBB:46:1:43 L-lysine is the only one known to have two distinct biosynthetic pathways: the diaminopimelate (DAP) pathway in plants, bacteria, and lower fungi, and the α-aminoadipate (AAA) pathway in euglenoids and higher fungi

The presence of the AAA pathway for lysine biosynthesis has been demonstrated in several yeasts and molds, including Saccharomyces cerevisiae (4,7), Yarrowia lipolytica (8), Schizosaccharomyces pombe (9), Rhodotorula glutinis (10), Candida maltosa (11), Neurospora crassa (12), and Penicillium chrysogenum (13); human pathogenic fungi, such as Candida albicans (14), and Cryptococcus neoformans (15), and Aspergillus fumigatus (15); and plant pathogens, including Magnaporthe grisea .....

DAP pathway

AAA pathway

[Antonialock]

so bacteria (and lower fungi? I don't know what these fungi are.....maybe early diverging?) use DAP pathway where lysine is one product, and "higher" fungi - pombe cerevisiae et al do the AAA pathway which doesn't produce lysine

https://link.springer.com/article/10.1007/s00726-014-1873-1

[Antonialock]

I'll have a look at these to remove...

[ValWood]

I don't know what lower and higher fungi are either ;)

[Antonialock]

this has been fixed under the hood.