PTN002351721 GO:0004742 | dihydrolipoyllysine-residue acetyltransferase activity for pdx1

[ValWood]

• PTHR ID & PTN node:

GO:0004742 | dihydrolipoyllysine-residue acetyltransferase activity | IBA with locus:2092070 , PTN002351721 , 619859 , P10515 , Q8IJJ4 , S000005015 | GO_REF:0000033

• Sequences with problematic annotation (ID + gene/protein name):

https://www.pombase.org/gene/SPCC1259.09c

PomBase pdx1 (S.c. ortholog PDX1 (YGR193C) is closely related to S000005015 LAT1 / YNL071W but they have different activities.

dihydrolipoyllysine-residue acetyltransferase activity for lat1

structural molecule activity for pdx1 described E3-binding protein of the mitochondrial pyruvate dehydrogenase complex; plays a structural role in the complex by binding and positioning dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide acetyltransferase (E2) core

• Type of Issue: Erroneous source or erroneous propagation, or other issue

• Add the label 'high priority' if needed. Generally high priority issues affect a lot of proteins, and annotations are incorrect (as opposed to just imprecise).

[ValWood]

They are related, same InterPro family https://www.pombase.org/gene_subset/interpro:IPR036625

but I assume there is a clear split?

[deustp01]

@sjm41 recently systematically reviewed and standardized GO terms for 2-oxoacid dehrdrogenase complexes and wrote up the results as a micropublication. Useful as a starting point for Val's new work, to ensure consistent results? micropub-biology-001209.pdf

[ValWood]

Thanks, useful!