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geneontology / go-announcements

Announcements related to ontology changes that may impact groups using GO, such as obsoletions, merges, etc.
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Obsoletion notice: children of GO:0061542 3-demethylubiquinol-n 3-O-methyltransferase activity #642

Closed pgaudet closed 10 months ago

pgaudet commented 10 months ago

Dear all,

The proposal has been made to obsolete GO:0008689 3-demethylubiquinone-9 3-O-methyltransferase activity GO:0044596 3-demethylubiquinol-10 3-O-methyltransferase activity GO:0061543 3-demethylubiquinol-6 3-O-methyltransferase activity GO:0099119 3-demethylubiquinol-8 3-O-methyltransferase activity & replace by parent GO:0061542 3-demethylubiquinol-n 3-O-methyltransferase activity

The reason for obsoletion is that these reactions are more specific than the specificity of the enzymes: the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.

Annotations are here: https://github.com/geneontology/go-annotation/issues/4868 Impacted groups: 1 SGD 1 EcoCyc 1 Reactome 3 UniRule/HAMAP

You can comment on the ticket: https://github.com/geneontology/go-ontology/issues/25680

Thanks, Pascale