The proposal has been made to obsolete GO:0043734 'DNA-N1-methyladenine dioxygenase activity'. The reason for obsoletion is that is defined with two substrates ( N1-methyladenine and N3-methylcytosine in DNA), which corresponds better to another existing term, GO:0035516 'oxidative DNA demethylase activity' defined as Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2.
GO:0043734 has no mappings, while GO:0035516 is mapped to EC:1.14.11.33 and RHEA:30299
GO:0043734 'DNA-N1-methyladenine dioxygenase activity' will be replaced by GO:0035516 'oxidative DNA demethylase activity.
Dear all,
The proposal has been made to obsolete GO:0043734 'DNA-N1-methyladenine dioxygenase activity'. The reason for obsoletion is that is defined with two substrates ( N1-methyladenine and N3-methylcytosine in DNA), which corresponds better to another existing term, GO:0035516 'oxidative DNA demethylase activity' defined as Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2.
GO:0043734 has no mappings, while GO:0035516 is mapped to EC:1.14.11.33 and RHEA:30299
GO:0043734 'DNA-N1-methyladenine dioxygenase activity' will be replaced by GO:0035516 'oxidative DNA demethylase activity.
There are 8 Uniprot annotations, 1 EcoCyc, and 2 Reactome mappings, see https://github.com/geneontology/go-annotation/issues/4880
You can comment on the ticket: https://github.com/geneontology/go-ontology/issues/26656
Thanks, Pascale