Enzyme obsoletion - GO-RHEA-EC alignment

Dear all,

The proposal has been made to obsolete the following terms, with replacements:

Unless otherwise state, the ticket is https://github.com/geneontology/go-ontology/issues/28070.

-GO:0102742 R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity >> replace by GO:0047995 hydroxyphenylpyruvate reductase activity; because GO:0102742 represents a specific substrate. No manual annotations

GO:0046563 methanol oxidase activity: EC was retired. No annotations
GO:0052589 malate dehydrogenase (menaquinone) activity (RHEA:30095): replace by GO:0008924 malate dehydrogenase (quinone) activity
GO:0102070 18-hydroxyoleate peroxygenase activity & replace by GO:1990137 plant seed peroxidase activity because GO:0102070 represents a specific substrate. No manual annotations
GO:0102300 linoleate 9R-lipoxygenase activity & replace by GO:0102299 linolenate 9R-lipoxygenase activity because GO:0102300 represents a specific substrate. No annotations
GO:0052860 2'-deoxymugineic-acid 3-dioxygenase activity & replace by GO:0033761 'mugineic-acid 3-dioxygenase activity' (enzyme has 2 substrates). No annotations
GO:0102804 oripavine 6-O-demethylase activity & replace by GO:0102802 thebaine 6-O-demethylase activity (enzyme has 2 substrates). No annotations
GO:0102566 1-acyl dihydroxyacetone phosphate reductase activity & replace by GO:0000140 acylglycerone-phosphate reductase activity because GO:0102566 represents a specific substrate. No manual annotations
GO:0102803 thebane O-demethylase activity & replace by GO:0102805 codeine O-demethylase activity because GO:0102803 represents a specific substrate. No annotations
GO:0106317 methane monooxygenase NADH activity and GO:0106318 methane monooxygenase NADPH activity into GO:0015049 methane monooxygenase activity; enzyme is not specific for NAD or NADP. No annotations
GO:0102321 2,2'-hydroxybiphenyl monooxygenase activity & replace by GO:0047544 2-hydroxybiphenyl 3-monooxygenase activity because GO:0047544 represents a specific substrate. No annotations
GO:0102977 nitrilotriacetate monooxygenase activity (FMN-dependent) & replace by GO:0018529 nitrilotriacetate monooxygenase activity. No annotations
GO:0102374 ursolic aldehyde 28-monooxygenase activity & replace by GO:0102373 uvaol dehydrogenase activity & change label to match EC: beta-amyrin 28-monooxygenase activity. No annotations
GO:0102136 3-epi-6-deoxocathasterone C-23 hydroxylase activity & replace by GO:0102097 (22S)-22-hydroxy-5alpha-campestan-3-one C-23 hydroxylase activity because GO:0102136 represents a specific substrate. No manual annotations
GO:0102290 beta-amyrin monooxygenase activity and GO:0102291 11alpha-hydroxy-beta-amyrin dehydrogenase activity & replace by GO:0102289 beta-amyrin 11-oxidase activity. These are sub-reactions of GO:0102289. No annotations.
GO:0047092 27-hydroxycholesterol 7-alpha-monooxygenase activity into GO:0033783 25-hydroxycholesterol 7alpha-hydroxylase activity because GO:0047092 represents a specific substrate. No annotations.
GO:0052616 ent-kaur-16-en-19-ol oxidase activity and GO:0052617 ent-kaur-16-en-19-al oxidase activity & replace by GO:0052615 ent-kaurene oxidase activity because these are subreactions. No manual annotations.
GO:0047103 3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase activity and GO:0047749 cholestanetriol 26-monooxygenase activity & replace by GO:0047748 cholestanetetraol 26-dehydrogenase activity (subreactions) - 1 EXP UniProt, will be automatically replaced.
GO:0102518 (11Z)-eicosenoate 14-hydroxylase activity & replace by GO:0050183 phosphatidylcholine 12-monooxygenase activity - specific substrate

You can comment on the ticket: https://github.com/geneontology/go-ontology/issues/28070

Thanks, Pascale

GO:0102786 stearoyl-[acp] desaturase activity >> replace by GO:0045300 acyl-[acyl-carrier-protein] desaturase activity; same reaction. 1 UniProt>> wil be automatically updated
All this group: GO:0102873 1-18:1-2-16:0-digalactosyldiacylglycerol desaturase activity GO:0102834 1-18:1-2-16:0-monogalactosyldiacylglycerol acyl-lipid omega-6 desaturase activity GO:0102836 1-18:1-2-16:1-monogalactosyldiacylglyceroldesaturase activity GO:0102838 1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity GO:0102841 1-18:1-2-16:2-monogalactosyldiacylglycerol synthase activity GO:0102655 1-18:1-2-trans-16:1-phosphatidylglycerol desaturase activity GO:0102844 1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity (SN2-16:2 forming)

replace by GO:0102850. acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) activity No annotations
All this group: GO:0102872 1-16:0-2-18:2-phosphatidylcholine desaturase activity GO:0102862 1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity (SN2-18:3 forming) GO:0102856 1-18:2-2-18:2-sn-glycerol-3-phosphocholine desaturase activity GO:0102854 1-18:2-2-18:1-phosphatidylcholine desaturase activity

replace by GO:0102859 acyl-lipid omega-3 desaturase (cytochrome b5) activity No annotations
All this group: GO:0102874 1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity GO:0102842 1-18:1-2-16:2-monogalactosyldiacylglycerol desaturase activity (SN2-16:3 forming) GO:0102835 1-18:2-2-16:0-monogalactosyldiacylglycerol desaturase activity GO:0102837 1-18:2-2-16:1-monogalactosyldiacylglycerol desaturase activity GO:0102839 1-18:2-2-16:2-monogalactosyldiacylglycerol desaturase activity GO:0102840 1-18:2-2-16:3-monogalactosyldiacylglycerol desaturase activity GO:0102848 1-18:2-2-18:2-digalactosyldiacylglycerol desaturase activity GO:0102875 1-18:2-2-18:2-monogalactosyldiacylglycerol desaturase activity GO:0102849 1-18:2-2-18:3-digalactosyldiacylglycerol desaturase activity

replace by GO:0102993 sn-2 acyl-lipid omega-3 desaturase (ferredoxin) activity No annotations
GO:0102657 1-18:1-2-16:0-monogalactosyldiacylglycerol palmitoyl-lipid 7-desaturase activity >> replace by GO:0102843 palmitoyl-[glycerolipid] 7-desaturase activity
GO:0102858 1-18:2-2-18:3-phosphatidylcholine desaturase activity](http://purl.obolibrary.org/obo/) : removed from MetaCyc (only source for the term)
GO:0018508 cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity >> deleted from MetaCyc, see https://github.com/geneontology/go-ontology/issues/28130. No annotations

Here are today’s obsoletions:

GO:0018492 carbon-monoxide dehydrogenase (acceptor) activity: replace by GO:0043885 carbon-monoxide dehydrogenase (ferredoxin) activity >> https://github.com/geneontology/go-ontology/issues/25872
GO:0052580 (+)-pulegone reductase, (-)-menthone as substrate, activity: replace by GO:0052579 (+)-pulegone reductase (NADP+) activity; single annotation to both terms to the same gene >> https://github.com/geneontology/go-ontology/issues/28161
GO:0102154 8C-naringenin dibenzoylmethane tautomer glucosyltransferase activity: replace by GO:0120514 2-hydroxyflavanone C-glucosyltransferase activity because GO:0102154 represents a specific substrate. No annotations. >> https://github.com/geneontology/go-ontology/issues/28159
GO:0102470 6C-naringenin dibenzoylmethane tautomer glucosyltransferase activity: replace by GO:0120514 2-hydroxyflavanone C-glucosyltransferase activity because GO:0102470 represents a specific substrate. No annotations. >> https://github.com/geneontology/go-ontology/issues/28159
GO:0102473 eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity: replace by GO:0120514 2-hydroxyflavanone C-glucosyltransferase activity because GO:0102473 represents a specific substrate. No annotations. >> https://github.com/geneontology/go-ontology/issues/28159
GO:0102474 eriodictyol dibenzoylmethane tautomer 6C-glucosyltransferase activity: replace by GO:0120514 2-hydroxyflavanone C-glucosyltransferase activity because GO:0102474 represents a specific substrate. No annotations. >> https://github.com/geneontology/go-ontology/issues/28159

The following terms are from the ‘duplicate EC’ ticket: https://github.com/geneontology/go-ontology/issues/28070

GO:0102853 1-18:1-2-18:1-sn-glycerol-3-phosphocholine desaturase activity & replace by GO:0050184 phosphatidylcholine desaturase activity because GO:0102853 represents a specific substrate. No annotations.
GO:0102851 1-18:2-2-16:0-phosphatidylglycerol desaturase activity & replace by GO:0102654 palmitoyl-[glycerolipid] 3-(E)-desaturase activity because GO:0102851 represents a specific substrate. No annotations.
GO:0102656 1-18:2-2-trans-16:1-phosphatidylglycerol desaturase activity: replace by GO:0102993 sn-2 acyl-lipid omega-3 desaturase (ferredoxin) activity because GO:0102656 represents a specific substrate. No annotations.
GO:0102845 1-18:3-2-16:0-monogalactosyldiacylglycerol desaturase activity & replace by GO:0102654 palmitoyl-[glycerolipid] 3-(E)-desaturase activity because GO:0102845 represents a specific substrate. No annotations.
GO:0102852 1-18:3-2-16:0-phosphatidylglycerol desaturase activity : replace by GO:0102654 palmitoyl-[glycerolipid] 3-(E)-desaturase activity because GO:0102852 represents a specific substrate. No annotations.
GO:0102846 1-18:3-2-16:1-monogalactosyldiacylglycerol desaturase activity: replace by GO:0102850 acyl-lipid (n+3)-(Z)-desaturase (ferredoxin) activity because GO:0102846 represents a specific substrate. No annotations.
GO:0102847 1-18:3-2-16:2-monogalactosyldiacylglycerol desaturase activity: replace by GO:0102993 sn-2 acyl-lipid omega-3 desaturase (ferredoxin) activity because GO:0102847 represents a specific substrate. No annotations.
GO:0102863 1-18:3-2-18:1-phosphatidylcholine desaturase activity : replace by GO:0050184 acyl-lipid omega-6 desaturase (cytochrome b5) activity because GO:0102863 represents a specific substrate. No annotations.
GO:0102864 1-18:3-2-18:2-phosphatidylcholine desaturase activity: replace by GO:0102859 acyl-lipid omega-3 desaturase (cytochrome b5) activity because GO:0102864 represents a specific substrate. No annotations.
GO:0102676 avenasterol-desaturase activity : replace by GO:0050046 delta7-sterol 5(6)-desaturase activity because GO:0102676 represents a specific substrate. No annotations.
GO:0102916 sesamin synthase activity: replaced by GO:0102915 piperitol synthase activity because GO:0102916 represents a specific substrate. No annotations.
GO:0102987 palmitoleic acid delta 12 desaturase activity: replace by GO:0102985 delta12-fatty-acid desaturase activity because GO:0102987 represents a specific substrate. 1 annotation (UniProt; removed, many other MFs)
GO:0018697 carbonyl sulfide nitrogenase activity: replace by GO:0016163 nitrogenase activity because GO:0018697 represents a specific substrate. No annotations.
GO:0102794 cinnamaldehyde:oxygen oxidoreductase activity: replace by GO:0018488 aryl-aldehyde oxidase activity because GO:0102794 represents a specific substrate. No annotations.
GO:0102796 protocatechualdehyde:oxygen oxidoreductase activity: replace by GO:0018488 aryl-aldehyde oxidase activity because GO:0102796 represents a specific substrate. No annotations.
GO:0102795 1-naphthaldehyde:oxygen oxidoreductase activity: replace by GO:0018488 aryl-aldehyde oxidase activity because GO:0102795 represents a specific substrate. No annotations.
GO:0102791 sulfuretin synthase activity: replace by GO:0033793 aureusidin synthase activity because GO:0102791 represents a specific substrate. No annotations.
GO:0102706 butein:oxygen oxidoreductase activity: replace by GO:0033793 aureusidin synthase activity because GO:0102706 represents a specific substrate. No annotations.
GO:0052886 9,9'-dicis-carotene:quinone oxidoreductase activity: replace by GO:0016719 9,9'-di-cis-zeta-carotene desaturase activity (sub-reaction) - 1 TAIR annotation; also annotated to GO:0016719
GO:0052887 7,9,9'-tricis-neurosporene:quinone oxidoreductase activity: replace by GO:0016719 9,9'-di-cis-zeta-carotene desaturase activity (sub-reaction) - no manual annotations
GO:0044318 L-aspartate:fumarate oxidoreductase activity: replace by GO:0008734 L-aspartate oxidase activity: enzyme can use O2 or fumarate as acceptor under different conditions. 1 EcoCyc annotation, already annotated to GO:0008734. Also add RHEA:30043 (narrowMatch)
GO:0052600 propane-1,3-diamine oxidase activity: replace with GO:0052597 diamine oxidase activity because GO:0052600 represents a specific substrate
GO:0052599 methylputrescine oxidase activity: replace with GO:0052597 diamine oxidase activity because GO:0052600 represents a specific substrate
GO:0052808 reduced coenzyme F420:NADP+ oxidoreductase activity: replace by GO:0102261 8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity: same reaction
GO:0018548 obsolete pentaerythritol trinitrate reductase activity: substrate more specific than any known enzyme. No annotations
GO:0050141 nitroethane oxidase activity: replace by parent GO:0052664 nitroalkane oxidase activity because GO:0050141 represents a specific substrate. Added RHEA:20976 and RHEA:26490 on GO:0052664.

Thanks, Pascale

GO:0102094 S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity: replace by GO:0043770 demethylmenaquinone methyltransferase activity because GO:0102094 represents a specific substrate. No annotations.
GO:0102955 S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity: replace by GO:0043770 demethylmenaquinone methyltransferase activity because GO:0102955 represents a specific substrate. No annotations.
GO:0102027 S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity: replace by GO:0043770 demethylmenaquinone methyltransferase activity because GO:0102955 represents a specific substrate. No annotations.
GO:0102308 erythromycin D 3''-o-methyltransferase activity >> replace by GO:0102307 erythromycin C 3''-o-methyltransferase activity & rename erythromycin 3''-o-methyltransferase activity; make EC exact and RHEA narrow. No annotations.
GO:0070448 laricitrin 5'-O-methyltransferase activity: replace by GO:0033799 myricetin 3'-O-methyltransferase activity and chage label to match EC, flavonoid 3',5'-methyltransferase. No annotations.
GO:0102918 (R)-reticuline 7-O-methyltransferase activity: replace by GO:0102917 (S)-reticuline 7-O-methyltransferase activity & rename as EC label, (R,S)-reticuline 7-O-methyltransferase activity; enzyme is non-stereo-specific. No annotations.
GO:0102707 S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity: replace by GO:0030748 amine N-methyltransferase activity - same activity. No annotations
GO:0102090 adrenaline O-methyltransferase activity : replace by GO:0016206 catechol O-methyltransferase activity because GO:0102090 represents a specific substrate. No annotations.
GO:0080101 phosphatidyl-N-dimethylethanolamine N-methyltransferase activity: replace by GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity because GO:0080101 represents a specific substrate. All annotations same.
GO:0102279 lecithin:11-cis retinol acyltransferase activity : replace by GO:0047173 phosphatidylcholine-retinol O-acyltransferase activity: represents the same reaction. No annotations.
GO:0102420 sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity: replace by GO:0004366 glycerol-3-phosphate O-acyltransferase activity
GO:0102815 caffeoyl-CoA:delphinidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity: replace by GO:0047183 anthocyanin 5-aromatic acyltransferase activity: represents the same reaction. No annotations.
GO:0102777 caffeoyl-CoA:pelargonidin-3,5-diglucoside 5-O-glucoside-6-O-hydroxycinnamoyltransferase activity: replace by GO:0047183 anthocyanin 5-aromatic acyltransferase activity: represents the same reaction. No annotations.
GO:0102920: acyl coenzyme A: isopenicillin N acyltransferase activity: replace with GO:0050640 isopenicillin-N N-acyltransferase activity because GO:0102920 represents a specific substrate. No annotations.
GO:0102588 cyanidin 3-O-glucoside 6''-O-malonyltransferase activity : replace with GO:0033809 anthocyanin 6''-O-malonyltransferase activity because GO:0102588 represents a specific substrate. No annotations.
GO:0102480 5-fluorocytosine deaminase activity: not a physiological susbtrate. No manual annotations.
GO:0102139 2-hydroxy-6-oxo-6-(2'-aminophenyl)-hexa-2,4dienoate hydrolase activity: replace by GO:0018768 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity; represents the same reaction. No annotations
GO:0043727 5-amino-4-imidazole carboxylate lyase activity: replace by GO:0004638 phosphoribosylaminoimidazole carboxylase activity; No annotations.
GO:0102361 esculetin 4-O-beta-glucosyltransferase activity : replace by GO:0047218 hydroxycinnamate 4-beta-glucosyltransferase activity because GO:0102361 represents a specific substrate. No manual annotations.
GO:0102359 daphnetin 4-O-beta-glucosyltransferase activity : replace by GO:0047218 hydroxycinnamate 4-beta-glucosyltransferase activity because GO:0102361 represents a specific substrate. No manual annotations.
GO:0102360 daphnetin 3-O-glucosyltransferase activity: replace by GO:0047893 flavonol 3-O-glucosyltransferase activity. No manual annotations.
GO:0102425 myricetin 3-O-glucosyltransferase activity: replace by GO:0047893 flavonol 3-O-glucosyltransferase activity. No manual annotations.
GO0102387 2-phenylethanol acetyltransferase activity: replace by acetyl-coenzyme A:acetyl alcohol acetyltransferase activity ; GO:0102720. No annotations
GO:0106325 acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity: replace by GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity: more specific than the activity of any known enzyme. No annotations.
GO:0106326 acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity: replace by: GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity: more specific than the activity of any known enzyme. No annotations.
GO:0102996 beta,beta digalactosyldiacylglycerol galactosyltransferase activity: replace by GO:0003844 1,4-alpha-glucan branching enzyme activity; GO:0102996 represents a specific substrate. No annotations
GO:0103101 UDP-glucose:7-methylthioheptylhydroximate S-glucosyltransferase activity
GO:0103102 UDP-glucose:8-methylthiooctylhydroximate S-glucosyltransferase activity
GO:0103100 UDP-glucose: 6-methylthiohexylhydroximate S-glucosyltransferase activity
GO:0103103 UDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity
GO:0102659 UDP-glucose: 4-methylthiobutylhydroximate S-glucosyltransferase activity
GO:0103099 UDP-glucose:5-methylthiopentylhydroximate S-glucosyltransferase activity

merge into GO:0047251 thiohydroximate beta-D-glucosyltransferase activity. Sprcific substrates. No annotations.
GO:0102500 beta-maltose 4-alpha-glucanotransferase activity: replace by GO:0004134 4-alpha-glucanotransferase activity; GO:0102500 represents a specific substrate. No annotations
GO:0102468 wogonin 7-O-glucuronosyltransferase activity & GO:0102467 scutellarein 7-O-glucuronosyltransferase activity >> merge into GO:0102159 baicalein 7-O-glucuronosyltransferase activity because they represent specific substrates. No annotations
GO:0102493 wogonin 7-O-glucosyltransferase activity : replace by GO:0033836 flavonol 7-O-beta-glucosyltransferase activity; represents a specific substrate. No annotations
GO:0102891 2'4'6'34-pentahydroxychalcone 4'-O-glucosyltransferase activity: replace by GO:0102890 naringenin chalcone 4'-O-glucosyltransferase activity: specific substrate. No annotations. Rename chalcone 4'-O-glucosyltransferase activity
GO:0102458 cyanidin 3-O-glucoside 5-O glucosyltransferase (vanilloyl-glucose dependent) activity
GO:0102456 cyanidin 3-O-glucoside 5-O-glucosyltransferase (sinapoyl-glucose dependent) activity
GO:0102512 delphinidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity
GO:0102510 pelargonidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity

Replace by GO:0102506 cyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity. Represent different acyl-glucose donors
GO:0103047 'methyl beta-D-glucoside 6-phosphate glucohydrolase activity' replace by GO:0008706 6-phospho-beta-glucosidase activity: represents a specific substrate.
GO:0102035 methylpropanoyl-CoA dehydrogenase activity: replace by GO:0003853 2-methylbutanoyl-CoA dehydrogenase activity & rename short-chain 2-methyl fatty acyl-CoA dehydrogenase activity, see https://github.com/geneontology/go-ontology/issues/26437. No annotations
GO:0004085 butyryl-CoA dehydrogenase activity: replace by short-chain fatty acyl-CoA dehydrogenase activity GO:0016937 since that also represents a specific substrate. 4 EXP annotations: RGD, AgBase, UniProt >> will be automatically remapped. See https://github.com/geneontology/go-ontology/issues/26437.
GO:0018778 DL-2 haloacid dehalogenase activity: same activity as (R)-2-haloacid dehalogenase activity ; GO:0033975 and (S)-2-haloacid dehalogenase ; GO:0018784.
GO:0018783 deisopropyldeethylatrazine hydrolase activity](http://purl.obolibrary.org/obo/) : xref [UM-BBD_reactionID:0129](http ://eawag-bbd.ethz.ch/servlets/pageservlet?ptype=r&reacID=0129) deprecated >> https://github.com/geneontology/go-ontology/issues/28188
GO:0018777 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity: represents a specific substrate of GO:0018786 haloalkane dehalogenase activity >> https://github.com/geneontology/go-ontology/issues/28188
GO:0102669 isoflavone-7-O-glucoside beta-glucosidase activity : represents a specific substrate of GO:0017042 glycosylceramidase activity. No annotations see https://github.com/geneontology/go-ontology/issues/25793.
GO:0035049 juvenile hormone acid methyltransferase activity: replace by GO:0019010 farnesoic acid O-methyltransferase activity; same genes annotated (FB) + Add EC:2.1.1.325 & RHEA, MetaCyc, and KEGG xrefs. see https://github.com/geneontology/go-ontology/issues/27388
GO:0102121 ceramidase activity: replace by GO:0017040 N-acylsphingosine amidohydrolase activity 1 EXP by ZFIN, will be automatically replaced. see https://github.com/geneontology/go-ontology/issues/27364

GO:0036141 L-phenylalanine-oxaloacetate transaminase activity: replace by GO:0080130 L-phenylalanine-2-oxoglutarate transaminase activity: same activity. No annotations
GO:0070546 L-phenylalanine transaminase activity: unnecessary grouping term. Consider: GO:0080130 L-phenylalanine-2-oxoglutarate transaminase activity and GO:0047312 L-phenylalanine-pyruvate transaminase activity. No annotations.
GO:0070547 : L-tyrosine aminotransferase activity: unnecessary grouping term. Consider: GO:0004838 L-tyrosine transaminase activity and GO:0080098 L-tyrosine:pyruvate aminotransferase activity No annotations.
- GO:0043840 branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity: represents a specific substrate of GO:0004084 branched-chain-amino-acid transaminase activity. No annotations
GO:0046571 aspartate-2-keto-4-methylthiobutyrate transaminase activity: represents a specific substrate of GO:0004084 branched-chain-amino-acid transaminase activity. No annotations
GO:0052819 heteroglycan 2-alpha-mannosyltransferase activity: replace by parent GO:0047264 heteroglycan alpha-mannosyltransferase activity. No annotations
GO:0052818 heteroglycan 3-alpha-mannosyltransferase activity: replace by parent GO:0047264 heteroglycan alpha-mannosyltransferase activity. No annotations
GO:0102638 [1-(2-amino-7-methyl-4-oxo-7,8-dihydro-3H-pteridin-6-yl)]ethyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase activity: replace by GO:0102041 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase ; represents a specific substrate. No annotations
GO:0102104 demethoxycurcumin synthase activity (0 annotations): merge into GO:0102103 demethoxycurcumin synthase activity; specific substrate
GO:0018733 3,4-dihydrocoumarin hydrolase activity: replace by GO:0047856 dihydrocoumarin hydrolase activity: represent the same activity. 1 EXP, will be automatically replaced
GO:0018732 sulfolactone hydrolase activity: replace by GO:0102998 4-sulfomuconolactone hydrolase activity ; represent the same activity
GO:0102402 2-phenylethyl 6-O-beta-D-xylopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity and GO:0102404 linalyl 6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranoside glucosidase (Yabukita) activity: replace by GO:0050535 beta-primeverosidase activity; represent specific substrates. No annotations
GO:0102253 neoagarobiose 1,3-alpha-3,6-anhydro-L-galactosidase activity, GO:0102256 neoagarohexaose 1,3-alpha-3,6-anhydro-L-galactosidase activity and GO:0102254 neoagarotetraose 1,3-alpha-3,6-anhydro-L-galactosidase activity: replace by GO:0033954 alpha-neoagaro-oligosaccharide hydrolase activity; represent specific substrates. No annotations
GO:0102151 3-oxo-myristate decarboxylase activity, GO:0102577 3-oxo-palmitate decarboxylase activity, GO:0102328 3-oxoacid decarboxylase activity >> replace by GO:0050410 3-oxolaurate decarboxylase activity; represent specific substrates. No annotations
GO:0051909 acetylenecarboxylate hydratase activity, producing 3-hydroxypropenoate: replace by GO:0050079 acetylenecarboxylate hydratase activity, producing 3-oxopropanoate & change label to acetylenecarboxylate hydratase activity. EC has comment "The reaction is effectively irreversible, favoring oxopropanoate (malonic semialdehyde) and its tautomers. Also acts on but-3-ynoate forming acetoacetate." No annotations
GO:0102056 11-hydroxyjasmonate sulfotransferase activity and GO:0102055 12-hydroxyjasmonate sulfotransferase activity; replace by GO:0080131 hydroxyjasmonate sulfotransferase activity. No manual annotations
GO:0102560 5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1-phosphohydrolase activity: replace by GO:0102561 D-ribose 2,5-bisphosphate 2-phosphohydrolase activity: very similar substrates, same gene annotated to both terms (1 annotation)
GO:0102507 cyanidin 3-O-glucoside 7-O-glucosyltransferase (hydroxybenzoly-glucose dependent) activity
GO:0102511 pelargonidin 3-O-glucoside 7-O-glucosyltransferase (acyl-glucose dependent) activity
GO:0102513 delphinidin 3-O-glucoside 5-O-glucosyltransferase (vanilloyl-glucose dependent) activity
GO:0102514 cyanidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity
GO:0102515 pelargonidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity
GO:0102516 delphinidin 3-O-glucoside 7-O-glucosyltransferase (feruloyl-glucose dependent) activity
GO:0102584 cyanidin 3-O-[2''-O-(xylosyl)-6''-O-(p-coumaroyl) glucoside] 5-O-glucosyltransferase activity

replace by GO:0102457 cyanidin 3-O-glucoside 7-O-glucosyltransferase (vanilloyl-glucose dependent) activity, because these represent specific substrates. No annotations to any of these terms.
GO:0102751 UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity; replace with GO:0008466 glycogenin glucosyltransferase activity : subreaction. 3 UniProt EXP, will be mapped automatically
GO:0102740 theobromine:S-adenosyl-L-methionine 1-N-methyltransferase activity: merge into GO:0102741 caffeine synthase activity because GO:0102740 represents a specific substrate. No annotations (broaden definition of GO:0102741)
GO:0052667 phosphomethylethanolamine N-methyltransferase activity merge into GO:0000234 phosphoethanolamine N-methyltransferase activity. EC states: "The enzyme may catalyze the transfer of two further methyl groups to the product." RHEA describes this as 3 reactions: RHEA:20365 (first methylation), RHEA:25321 (second) and RHEA:25325 (third). 1 EXP, TAIR. Will be automatically replaced
GO:0102128 chalcone synthase activity : replace by GO:0016210 naringenin-chalcone synthase activity: specific substrate.

geneontology / go-announcements

Enzyme obsoletion - GO-RHEA-EC alignment #769