gocentral
commented
11 years ago Hi Chris,
Radial glia are not restricted to the forebrain, see PMID:9136766. I think the synonym in cell needs to be relaxed.
One general rule of thumb when looking at any part of the ontology that was the result of a focused meeting with experts is that if we have a specific term like this one, it is almost always the case that I asked the experts if we need to qualify the term because the process can happen elsewhere. If you's like, we can chat and I'll give you an example of how those conversations unfold at the meetings. It basically starts with us asking the experts to give us the parts of a process and then we ask them if the part that they have told us can happen as part of any other process. If they say yes then we qualify the term to restrict it to the parental whole. This is a standard practice at these meetings.
Do you want me to change the GO def to:
"The process in which neuroepithelial cells of the neural tube give rise to radial glial cells that are located in the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate."
-D
Original comment by: ukemi
Are "radial glial cells" found anywhere except the forebrain?
The embedded def here suggests this is the case: This embedded def is confusing:
GO:0021861 ! forebrain radial glial cell differentiation [DEF: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate."]
It makes it sound as if all radial glial cells are in the forebrain. However, we also have a term for spinal cord
This sounds nit-picky but there is confusion here that hampers x-cell. See for example:
[Term] id: CL:0000681 name: radial glial cell def: "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration." [GOC:dph] comment: Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence ofnradial glial cells acting as neural progenitors throughout life. *synonym: "forebrain radial glial cell" EXACT** [] is_a: CL:0000243 ! glial cell (sensu Vertebrata) relationship: develops_from CL:0000031 ! neuroblast
I suggest:
-CL def is agreed upon -CL exact syn is weakened or removed -(optionally) adding two subclasses in CL (as of our discussion today this is the best strategy)
I won't put this on the CL tracker - I think we need to tackle this in an integrated but GO-centric way
Reported by: cmungall
Original Ticket: geneontology/ontology-requests/10065