Other term-related request: additional parentage for prefoldin complex?

[gocentral]

Hi,

The prefoldin complex (GO:0016272) is a cytoplasmic complex involved in protein folding. However, PMID:24068951 shows that in yeast it is additionally present in the nucleus and has a role in facilitating transcriptional elongation. Not sure if additional parentage is the best way to address this - what do you think?

Thanks, Maria

Reported by: mariacostanzo

Original Ticket: geneontology/ontology-requests/10442

[gocentral]

• assigned_to: David Osumi-Sutherland

Original comment by: dosumis

[gocentral]

Removed classification as cytosolic. Modified definition to take into account conclusions of referenced paper. Please check and let me know if the following is OK:

[Term] id: GO:0016272 name: prefoldin complex namespace: cellular_component def: "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:9630229, PMID:24068951] subset: gosubset_prok synonym: "GIM complex" NARROW [] xref: Wikipedia:Prefoldin is_a: GO:0043234 ! protein complex

Cheers, David

Original comment by: dosumis

[gocentral]

• status: open --> closed-fixed

Original comment by: dosumis

[gocentral]

Thanks David, that looks good!

Original comment by: mariacostanzo